A pre-S/S CHO-derived hepatitis B virus vaccine protects woodchucks from WHV productive infection

被引：7

作者：

Argentini, C

Giuseppetti, R

D'Ugo, E

La Sorsa, V

Tritarelli, E

Orobello, S

Canitano, A

Glück, R

Rapicetta, M

机构：

[1] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, Viral Hepatitis Unit, I-00161 Rome, Italy

[2] Berna Biotech Ltd, CH-3018 Bern, Switzerland

来源：

VACCINE | 2005年 / 23卷 / 28期

关键词：

HBV vaccine; woodchuck hepatitis virus; animal model;

D O I：

10.1016/j.vaccine.2005.02.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated whether a non-adjuvanted vaccine derived from Chinese hamster ovary cells was capable of providing protection against woodchuck hepatitis virus (WHV). Three woodchucks were vaccinated with four 50-mg doses and challenged with a previously characterized virus isolate (WHV197). In all three animals, titre levels of antibodies against hepatitis B surface antigens (anti-HBs) exceeded 10 mIU/ml, peaking at 150 mIU/ml. Challenge resulted in productive acute infection in the two non-vaccinated woodchucks yet in none of the vaccinated woodchucks. In the vaccinated animals, there was evidence of abortive infection. The results demonstrate that a human vaccine is able to protect woodchucks from WHV infection. 2005 Elsevier Ltd. All rights reserved.

引用

页码：3649 / 3656

页数：8

共 46 条

[1]

ALBERTI A, 1988, LANCET, V1, P1421

[2] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine [J].

Amara, RR ;

Villinger, F ;

Altman, JD ;

Lydy, SL ;

O'Neil, SP ;

Staprans, SI ;

Montefiori, DC ;

Xu, Y ;

Herndon, JG ;

Wyatt, LS ;

Candido, MA ;

Kozyr, NL ;

Earl, PL ;

Smith, JM ;

Ma, HL ;

Grimm, BD ;

Hulsey, ML ;

Miller, J ;

McClure, HM ;

McNicholl, JM ;

Moss, B ;

Robinson, HL .

SCIENCE, 2001, 292 (5514) :69-74

[3] OVERVIEW OF A 5-YEAR CLINICAL-EXPERIENCE WITH A YEAST-DERIVED HEPATITIS-B VACCINE [J].

ANDRE, FE .

VACCINE, 1990, 8 :S74-S78

[4] Hepadnavirus evolution and molecular strategy of adaptation in a new host [J].

Argentini, C ;

La Sorsa, V ;

Bruni, R ;

D'Ugo, E ;

Giuseppetti, R ;

Rapicetta, M .

JOURNAL OF GENERAL VIROLOGY, 1999, 80 :617-626

[5] Antigen-specific T cell response in infants after recombinant hepatitis B virus vaccination at birth: evaluation of T helper lymphocyte diversity [J].

Avanzini, MA ;

Belloni, C ;

De Silvestri, A ;

Castellazzi, AM ;

Marconi, M ;

Moretta, A ;

Montagna, D ;

Martinetti, M ;

Cuccia, M ;

Rondini, G ;

Ciardelli, L ;

Maccario, R .

CLINICAL IMMUNOLOGY, 2003, 107 (02) :122-128

[6] Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination [J].

Barouch, DH ;

Santra, S ;

Schmitz, JE ;

Kuroda, MJ ;

Fu, TM ;

Wagner, W ;

Bilska, M ;

Craiu, A ;

Zheng, XX ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Nickerson, CE ;

Trigona, WL ;

Punt, K ;

Freed, DC ;

Guan, LM ;

Dubey, S ;

Casimiro, D ;

Simon, A ;

Davies, ME ;

Chastain, M ;

Strom, TB ;

Gelman, RS ;

Montefiori, DC ;

Lewis, MG ;

Emini, EA ;

Shiver, JW ;

Letvin, NL .

SCIENCE, 2000, 290 (5491) :486-492

[7] VACCINE-INDUCED ESCAPE MUTANT OF HEPATITIS-B VIRUS [J].

CARMAN, WF ;

ZANETTI, AR ;

KARAYIANNIS, P ;

WATERS, J ;

MANZILLO, G ;

TANZI, E ;

ZUCKERMAN, AJ ;

THOMAS, HC .

LANCET, 1990, 336 (8711) :325-329

[8]

*CDC, 1991, JAMA-J AM MED ASSOC, V266, P1338

[9]

CHISARI FV, 1996, VIRAL HEPATITIS LIVE, P405

[10] PROTECTION OF CHIMPANZEES FROM TYPE-B HEPATITIS BY IMMUNIZATION WITH WOODCHUCK HEPATITIS-VIRUS SURFACE-ANTIGEN [J].

COTE, PJ ;

SHAPIRO, M ;

ENGLE, RE ;

POPPER, H ;

PURCELL, RH ;

GERIN, JL .

JOURNAL OF VIROLOGY, 1986, 60 (03) :895-901

← 1 2 3 4 5 →