Floating Ricobendazole Delivery Systems: A 3D Printing Method by Co-Extrusion of Sodium Alginate and Calcium Chloride

被引:20
作者
Falcone, Giovanni [1 ,2 ]
Real, Juan P. [3 ,4 ]
Palma, Santiago D. [3 ,4 ]
Aquino, Rita P. [1 ]
Del Gaudio, Pasquale [1 ]
Garofalo, Emilia [5 ]
Russo, Paola [1 ]
机构
[1] Univ Salerno, Dept Pharm, I-84084 Fisciano, Italy
[2] Univ Salerno SA, PhD Program Drug Discovery & Dev, I-84081 Fisciano, Italy
[3] Consejo Nacl Invest Cient & Tecn, Unidad Invest & Desarrollo Tecnol Farmaceut UNITE, X5000HUA, Cordoba, Argentina
[4] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Ciencias Farmaceut, Ciudad Univ,X5000HUA, Cordoba, Argentina
[5] Univ Salerno, Dept Ind Engn, I-84081 Fisciano, Italy
关键词
semi-solid extrusion 3D printing; alginate ionotropic gelation; floating DDS; DRUG-DELIVERY; PHARMACOKINETICS; ALBENDAZOLE; RELEASE;
D O I
10.3390/ijms23031280
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
At present, the use of benzimidazole drugs in veterinary medicine is strongly limited by both pharmacokinetics and formulative issues. In this research, the possibility of applying an innovative semi-solid extrusion 3D printing process in a co-axial configuration was speculated, with the aim of producing a new gastro-retentive dosage form loaded with ricobendazole. To obtain the drug delivery system (DDS), the ionotropic gelation of alginate in combination with a divalent cation during the extrusion was exploited. Two feeds were optimized in accordance with the printing requirements and the drug chemical properties: the crosslinking ink, i.e., a water ethanol mixture containing CaCl2 at two different ratios 0.05 M and 0.1 M, hydroxyethyl cellulose 2% w/v, Tween 85 0.1% v/v and Ricobendazole 5% w/v; and alginate ink, i.e., a sodium alginate solution at 6% w/v. The characterization of the dried DDS obtained from the extrusion of gels containing different amounts of calcium chloride showed a limited effect on the ink extrudability of the crosslinking agent, which on the contrary strongly influenced the final properties of the DDS, with a difference in the polymeric matrix toughness and resulting effects on floating time and drug release.
引用
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页数:14
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