A Multicolor Nanoprobe for Detection and Imaging of Tumor-Related mRNAs in Living Cells

被引：312

作者：

Li, Na ^{[1
]}

Chang, Chenyang ^{[1
]}

Pan, Wei ^{[1
]}

Tang, Bo ^{[1
]}

机构：

[1] Shandong Normal Univ, Engn Res Ctr Pesticide & Med Intermediate Clean P, Key Lab Mol & Nano Probes, Coll Chem Chem Engn & Mat Sci,Minist Educ, Jinan 250014, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 30期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

gold; mRNA; multicolor nanoprobes; nanoparticles; cancer detection; BREAST-CANCER; THYMIDINE KINASE; GOLD NANOPARTICLES; MOLECULAR BEACONS; GENE-EXPRESSION; NANO-FLARES; DNA; MARKER; MYC; FLUORESCENCE;

D O I：

10.1002/anie.201203767

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multidetector: A novel nanoprobe, based on multicolor nanoflares, for the simultaneous detection and imaging of three tumor-related mRNAs in living cells has been developed. The nanoprobe possesses high specificity, nuclease stability, and good biocompatibility. It can also effectively distinguish cancer cells from normal cells and identify changes in the levels of mRNA expression. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7426 / 7430

页数：5

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