The KCNQ1 potassium channel: From gene to physiological function

被引：218
作者：
Jespersen, T
Grunnet, M
Olesen, SP
机构：
[1] Univ Copenhagen, Panum Inst, Dept Med Physiol, DK-2200 Copenhagen, Denmark
[2] Univ Copenhagen, Panum Inst, Danish Arrhythmia Res Ctr, Copenhagen, Denmark
[3] NeuroSearch, Ballerup, Denmark
来源：
PHYSIOLOGY | 2005年 / 20卷
关键词：
D O I：
10.1152/physiol.00031.2005
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.
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收藏
页码：408 / 416
页数：9
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