Feasibility of unconstrained three-material decomposition: imaging an excised human heart using a prototype silicon photon-counting CT detector

被引:26
作者
Gronberg, Fredrik [1 ]
Lundberg, Johan [2 ,3 ]
Sjolin, Martin [1 ]
Persson, Mats [1 ,4 ]
Bujila, Robert [5 ]
Bornefalk, Hans [1 ]
Almqvist, Hakan [2 ,3 ]
Holmin, Staffan [2 ,3 ]
Danielsson, Mats [1 ]
机构
[1] KTH Royal Inst Technol, AlbaNova Univ Ctr, Dept Phys, SE-10691 Stockholm, Sweden
[2] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
[3] Karolinska Univ Hosp, Dept Neuroradiol, Stockholm, Sweden
[4] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
[5] Karolinska Univ Hosp, Med Radiat Phys & Nucl Med, Stockholm, Sweden
关键词
Tomography; X-ray computed; Contrast media; Plaque; atherosclerotic; Algorithms; Phantoms; imaging; COMPUTED-TOMOGRAPHY; CHEST-PAIN; RISK PREDICTION; STRIP DETECTOR; SPECTRAL CT; NOISE; CIRCUMFERENCE; RESOLUTION; PLAQUE; BIN;
D O I
10.1007/s00330-020-07017-y
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Rationale and objectives The purpose of this study was to evaluate the feasibility of unconstrained three-material decomposition in a human tissue specimen containing iodinated contrast agent, using an experimental multi-bin photon-counting silicon detector. It was further to evaluate potential added clinical value compared to a 1st-generation state-of-the-art dual-energy computed tomography system. Materials and methods A prototype photon-counting silicon detector in a bench-top setup for x-ray tomographic imaging was calibrated using a multi-material calibration phantom. A heart with calcified plaque was obtained from a deceased patient, and the coronary arteries were injected with an iodinated contrast agent mixed with gelatin. The heart was imaged in the experimental setup and on a 1st-generation state-of-the-art dual-energy computed tomography system. Projection-based three-material decomposition without any constraints was performed with the photon-counting detector data, and the resulting images were compared with those obtained from the dual-energy system. Results The photon-counting detector images show better separation of iodine and calcium compared to the dual-energy images. Additional experiments confirmed that unbiased estimates of soft tissue, calcium, and iodine could be achieved without any constraints. Conclusion The proposed experimental system could provide added clinical value compared to current dual-energy systems for imaging tasks where mix-up of iodine and calcium is an issue, and the anatomy is sufficiently small to allow iodine to be differentiated from calcium. Considering its previously shown count rate capability, these results show promise for future integration of this detector in a clinical CT scanner.
引用
收藏
页码:5904 / 5912
页数:9
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