Detection of oxidized LDL using a carbon nanotube electrode

被引：9

作者：

Takeda, Seiji ^{[1
]}

Hui, Shu-Ping ^{[1
]}

Fukuda, Keisuke ^{[1
]}

Fuda, Hirotoshi ^{[1
]}

Jin, Shigeki ^{[1
]}

Sakurai, Toshihiro ^{[1
]}

Ishii, Atsushi ^{[1
,2
]}

Mukasa, Koichi ^{[1
,2
]}

Sueoka, Kazuhisa ^{[3
]}

Chiba, Hitoshi ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Hlth Sci, Sapporo, Hokkaido 0600812, Japan

[2] Biosensor Inc, Sapporo, Hokkaido 0600051, Japan

[3] Hokkaido Univ, Grad Sch Informat Sci & Technol, Sapporo, Hokkaido 0600814, Japan

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2012年 / 166卷

基金：

日本学术振兴会;

关键词：

Sensor; Lipid; Lipoprotein; Oxidation; Nanotube; ELECTROCHEMICAL IMMUNOSENSOR; LIPOPROTEIN;

D O I：

10.1016/j.snb.2012.02.064

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Oxidized low-density lipoproteins (LDLs) play a key role in cardiovascular disease development, but no convenient measurement method is available for them. Using a carbon nanotube (CNT) electrode, we measured oxidized LDL using amperometric detection. Treating SWCNT with a mixture of acids produced a CNT dispersion that yielded nanotube-based electrodes after deposition on a gold electrode and drying. Current was monitored in the nanotube electrode before and after adding LDL or oxidization of LDL Oxidized LDL changed the current more than 10 nA, although LDL addition induced no significant change. Our CNT electrode enables simple detection of oxidized LDL. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：833 / 836

页数：4

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