Analysis of the association of clinical factors and IL4 gene polymorphisms with root resorption in avulsed teeth after 1year of replantation

AimTo investigate the association of clinical variables and polymorphisms (tag SNPs) in the interleukin 4 (IL4) gene, with the prognosis of avulsed and replanted teeth. MethodologyNinety-four patients who suffered avulsion and had their teeth replanted and endodontically treated were included. Periapical radiographs were obtained soon after tooth replantation and after 1year. For genotypic IL4 gene analysis, the DNA from oral mucosa cells was collected, and polymorphisms were investigated by real-time PCR. Univariate and multivariate analyses were performed to verify the association of clinical and genetic variables and the outcome of the replanted teeth (P<0.05). ResultsAfter multivariate analysis, extra-alveolar time longer than 1h was significantly associated with external root resorption. No significant association was observed between IL4 gene polymorphisms and root resorption. ConclusionNo association between root resorption and IL4 gene polymorphisms was observed. An extra-alveolar time of more than 1h was associated with a susceptibility for external root resorption. Replanting the tooth in its socket immediately is the most important factor to maintain a healthy root surface.