Pharmacogenetics and anesthesiologists

被引：20

作者：

Galley, HF ^{[1
]}

Mahdy, A ^{[1
]}

Lowes, DA ^{[1
]}

机构：

[1] Univ Aberdeen, Acad Unit Anaesthesia & Intens Care, Sch Med, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

PHARMACOGENOMICS | 2005年 / 6卷 / 08期

关键词：

analgesia; anesthesia; anesthesiology; genetics; pharmacodynamics; pharmacokinetics; polymorphism;

D O I：

10.2217/14622416.6.8.849

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Genetic variation contributes to an individual's sensitivity and response to a variety of drugs important to anesthetic practice. Early insights into the clinical impact of pharmacogenetics were provided by anesthesiology - investigations into prolonged apnea after succinylcholine administration, thiopental-induced porphyria and malignant hyperthermia contributed to the novel science of pharmacogenetics in the early 1960s. Genetic polymorphisms involved in pharmacokinetics (absorption, distribution, metabolism, and excretion of drugs) and pharmacodynamics (receptors, ion channels and enzymes) can affect an individual's response to the drugs used in anesthetic practice. In addition, genetic variation in proteins directly unrelated to drug action or metabolism can influence responses to environmental changes that occur during anesthesia. This review will summarize the current knowledge of genetic variation in response to drugs relevant to anesthesia, and how this impacts upon clinical practice.

引用

页码：849 / 856

页数：8

共 63 条

[1] A single nucleotide polymorphic mutation in the human μ-opioid receptor severely impairs receptor signaling [J].