Association of hypogonadism with vitamin D status: the European Male Ageing Study

被引：150

作者：

Lee, David M. ^{[2
]}

Tajar, Abdelouahid ^{[2
]}

Pye, Stephen R. ^{[2
]}

Boonen, Steven ^{[3
,4
]}

Vanderschueren, Dirk ^{[5
]}

Bouillon, Roger ^{[6
]}

O'Neill, Terence W. ^{[2
]}

Bartfai, Gyorgy ^{[7
]}

Casanueva, Felipe F. ^{[8
,9
]}

Finn, Joseph D. ^{[1
]}

Forti, Gianni ^{[10
]}

Giwercman, Aleksander ^{[11
]}

Han, Thang S. ^{[12
]}

Huhtaniemi, Ilpo T. ^{[13
]}

Kula, Krzysztof ^{[14
]}

Lean, Michael E. J. ^{[15
]}

Pendleton, Neil ^{[16
]}

Punab, Margus ^{[17
]}

Wu, Frederick C. W. ^{[1
]}

机构：

[1] Univ Manchester, Manchester Royal Infirm, Manchester Acad Hlth Sci Ctr, Dev & Regenerat Biomed Res Grp,Androl Res Unit, Manchester M13 9WL, Lancs, England

[2] Univ Manchester, Manchester Acad Hlth Sci Ctr, Arthrit Res UK Epidemiol Unit, Manchester M13 9PT, Lancs, England

[3] Katholieke Univ Leuven, Dept Expt Med, Div Gerontol & Geriatr, B-3000 Louvain, Belgium

[4] Katholieke Univ Leuven, Dept Expt Med, Ctr Musculoskeletal Res, B-3000 Louvain, Belgium

[5] Katholieke Univ Leuven, Dept Androl & Endocrinol, B-3000 Louvain, Belgium

[6] Katholieke Univ Leuven, Dept Expt Med, B-3000 Louvain, Belgium

[7] Albert Szent Gyorgyi Med Univ, Dept Obstet Gynaecol & Androl, H-6725 Szeged, Hungary

[8] Univ Santiago de Compostela, CHUS, Dept Med, Santiago De Compostela 15076, Spain

[9] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Santiago De Compostela 15076, Spain

[10] Univ Florence, Dept Clin Physiopathol, Androl Unit, I-50019 Florence, Italy

[11] Lund Univ, Malmo Univ Hosp, Reprod Med Ctr, SE-20506 Lund, Sweden

[12] Royal Free Hosp, Royal Free & Univ Coll Hosp Med Sch, Dept Endocrinol, London NW3 2QG, England

[13] Univ London Imperial Coll Sci Technol & Med, Dept Reprod Biol, London W12 0HS, England

[14] Med Univ Lodz, Dept Androl & Reprod Endocrinol, PL-90419 Lodz, Poland

[15] Univ Glasgow, Dept Human Nutr, Glasgow G12 8QQ, Lanark, Scotland

[16] Univ Manchester, Salford Royal Hosp, Sch Community Based Med, Salford M6 8HD, Lancs, England

[17] Tartu Univ Clin, United Labs, Androl Unit, EE-50406 Tartu, Estonia

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2012年 / 166卷 / 01期

关键词：

D DEFICIENCY; D-RECEPTOR; CARDIOVASCULAR-DISEASE; FREE TESTOSTERONE; D INSUFFICIENCY; OLDER MEN; SERUM; RISK; METAANALYSIS; SECONDARY;

D O I：

10.1530/EJE-11-0743

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Interrelationships between hormones of the hypothalamic-pituitary-testicular (HPT) axis, hypogonadism, vitamin D and seasonality remain poorly defined. We investigated whether HPT axis hormones and hypogonadism are associated with serum levels of 25-hydroxyvitamin D (25(OH)D) in men. Design and methods: Cross-sectional survey of 3369 community-dwelling men aged 40-79 years in eight European centres. Testosterone (T), oestradiol (E-2) and dihydrotestosterone were measured by gas chromatography-mass spectrometry; LH, FSH, sex hormone binding globulin (SHBG), 25(OH)D and parathyroid hormone by immunoassay. Free T was calculated from total T, SHBG and albumin. Gonadal status was categorised as eugonadal (normal T/LH), secondary (low T, low/normal LH), primary (low T, elevated LH) and compensated (normal T, elevated LH) hypogonadism. Associations of HPT axis hormones with 25(OH)D were examined using linear regression and hypogonadism with vitamin D using multinomial logistic regression. Results: In univariate analyses, free T levels were lower (P=0.02) and E-2 and LH levels were higher (P<0.05) in men with vitamin D deficiency (25(OH)D <50 nmol/l). 25(OH)D was positively associated with total and free T and negatively with E-2 and LH in age- and centre-adjusted linear regressions. After adjusting for health and lifestyle factors, no significant associations were observed between 25(OH)D and individual hormones of the HPT axis. However, vitamin D deficiency was significantly associated with compensated (relative risk ratio (RRR)=1.52, P=0.03) and secondary hypogonadism (RRR=1.16, P=0.05). Seasonal variation was only observed for 25(OH)D (P<0.001). Conclusions: Secondary and compensated hypogonadism were associated with vitamin D deficiency and the clinical significance of this relationship warrants further investigation.

引用

页码：77 / 85

页数：9

共 32 条

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