Extracorporeal Photopheresis in Graft-versus-Host Disease

被引：43

作者：

Drexler, Beatrice ^{[1
,2
]}

Buser, Andreas ^{[1
,2
]}

Infanti, Laura ^{[1
,2
]}

Stehle, Gregor ^{[1
,2
]}

Halter, Joerg ^{[1
]}

Holbro, Andreas ^{[1
,2
]}

机构：

[1] Univ Hosp Basel, Div Hematol, Petersgraben 4, CH-4031 Basel, Switzerland

[2] Swiss Red Cross, Ctr Blood Transfus, Basel, Switzerland

来源：

TRANSFUSION MEDICINE AND HEMOTHERAPY | 2020年 / 47卷 / 03期

关键词：

Extracorporeal photopheresis; Treatment; Graft-versus-host disease; STEM-CELL TRANSPLANTATION; CONSENSUS DEVELOPMENT PROJECT; THERAPEUTIC APHERESIS; PEDIATRIC-PATIENTS; CLINICAL-PRACTICE; CHRONIC GVHD; PHOTOCHEMOTHERAPY; SURVIVAL; LYMPHOMA; ECP;

D O I：

10.1159/000508169

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and Summary:Extracorporeal photopheresis (ECP) is a leukapheresis-based procedure used in the therapy of acute and chronic graft-versus-host disease (aGvHD, cGvHD) and other diseases. Based on the substantial efficacy and the excellent safety profile in the absence of immunosuppression ECP has established itself as a major treatment form for steroid-refractory GvHD. Here we review the current literature on ECP as a treatment option for patients with aGvHD as well as cGvHD.Key Messages:ECP is a well-established second-line therapy for cGvHD. Its role in the treatment of aGvHD is less clear but also points towards an effective second-line therapy option. In the future ECP could play a role in the prevention of GvHD. More experimental and randomized controlled trials are needed to define the best patient selection criteria, settings, and therapy regimens for GvHD.

引用

页码：214 / 224

页数：11

共 70 条

[21]

Garban F, 2005, HAEMATOLOGICA, V90, P1096

[22] Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells [J].

Gatza, Erin ;

Rogers, Clare E. ;

Clouthier, Shawn G. ;

Lowler, Kathleen P. ;

Tawara, Isao ;

Liu, Chen ;

Reddy, Pavan ;

Ferrara, James L. M. .

BLOOD, 2008, 112 (04) :1515-1521

[23] Investigation of annexin V binding to lymphocytes after extracorporeal photoimmunotherapy as an early marker of apoptosis [J].

Gerber, A ;

Bohne, M ;

Rasch, J ;

Struy, H ;

Ansorge, S ;

Gollnick, H .

DERMATOLOGY, 2000, 201 (02) :111-117

[24] Extracorporeal photochemotherapy for steroid-refractory graft-versus-host disease in low-weight pediatric patients.: Immunomodulatory effects and clinical outcome [J].

Gonzalez-Vicent, Marta ;

Ramirez, Manuel ;

Perez, Antonio ;

Lassaletta, Alvaro ;

Sevilla, Julian ;

Diaz, Miguel Angel .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (08) :1278-1280

[25] Assessing the potential role of photopheresis in hematopoietic stem cell transplant [J].

Greinix, H. T. ;

Socie, G. ;

Bacigalupo, A. ;

Holler, E. ;

Edinger, M. G. ;

Apperley, J. F. ;

Schwarz, T. ;

Ullrich, S. E. ;

Albert, M. L. ;

Knobler, R. M. ;

Peritt, D. ;

Ferrara, J. L. M. .

BONE MARROW TRANSPLANTATION, 2006, 38 (04) :265-273

[26]

Greinix HT, 2006, HAEMATOLOGICA, V91, P405

[27] Extracorporeal photopheresis in acute and chronic graft-versus-host disease [J].

Greinix, Hildegard T. ;

Worel, Nina ;

Just, Ulrike ;

Knobler, Robert .

TRANSFUSION AND APHERESIS SCIENCE, 2014, 50 (03) :349-357

[28] Progressive Improvement in Cutaneous and Extracutaneous Chronic Graft-versus-Host Disease after a 24-Week Course of Extracorporeal Photopheresis-Results of a Crossover Randomized Study [J].

Greinix, Hildegard T. ;

van Besien, Koen ;

Elmaagacli, Ahmet H. ;

Hillen, Uwe ;

Grigg, Andrew ;

Knobler, Robert ;

Parenti, Dennis ;

Reddy, Vijay ;

Theunissen, Koen ;

Michallet, Mauricette ;

Flowers, Mary E. D. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2011, 17 (12) :1775-1782

[29] Role of Extracorporeal Photopheresis (ECP) in Treatment of Steroid-Refractory Acute Graft-versus-Host Disease [J].

Greinix, Hildegard T. ;

Worel, Nina ;

Knobler, Robert .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (12) :1747-1748

[30]

Greinix HT, 2000, BLOOD, V96, P2426

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