Extracorporeal Photopheresis in Graft-versus-Host Disease

被引：43

作者：

Drexler, Beatrice ^{[1
,2
]}

Buser, Andreas ^{[1
,2
]}

Infanti, Laura ^{[1
,2
]}

Stehle, Gregor ^{[1
,2
]}

Halter, Joerg ^{[1
]}

Holbro, Andreas ^{[1
,2
]}

机构：

[1] Univ Hosp Basel, Div Hematol, Petersgraben 4, CH-4031 Basel, Switzerland

[2] Swiss Red Cross, Ctr Blood Transfus, Basel, Switzerland

来源：

TRANSFUSION MEDICINE AND HEMOTHERAPY | 2020年 / 47卷 / 03期

关键词：

Extracorporeal photopheresis; Treatment; Graft-versus-host disease; STEM-CELL TRANSPLANTATION; CONSENSUS DEVELOPMENT PROJECT; THERAPEUTIC APHERESIS; PEDIATRIC-PATIENTS; CLINICAL-PRACTICE; CHRONIC GVHD; PHOTOCHEMOTHERAPY; SURVIVAL; LYMPHOMA; ECP;

D O I：

10.1159/000508169

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and Summary:Extracorporeal photopheresis (ECP) is a leukapheresis-based procedure used in the therapy of acute and chronic graft-versus-host disease (aGvHD, cGvHD) and other diseases. Based on the substantial efficacy and the excellent safety profile in the absence of immunosuppression ECP has established itself as a major treatment form for steroid-refractory GvHD. Here we review the current literature on ECP as a treatment option for patients with aGvHD as well as cGvHD.Key Messages:ECP is a well-established second-line therapy for cGvHD. Its role in the treatment of aGvHD is less clear but also points towards an effective second-line therapy option. In the future ECP could play a role in the prevention of GvHD. More experimental and randomized controlled trials are needed to define the best patient selection criteria, settings, and therapy regimens for GvHD.

引用

页码：214 / 224

页数：11

共 70 条

[1] The role of extracorporeal photopheresis in the management of cutaneous T-cell lymphoma, graft-versus-host disease and organ transplant rejection: a consensus statement update from the UK Photopheresis Society [J].

Alfred, Arun ;

Taylor, Peter C. ;

Dignan, Fiona ;

El-Ghariani, Khaled ;

Griffin, James ;

Gennery, Andrew R. ;

Bonney, Denise ;

Das-Gupta, Emma ;

Lawson, Sarah ;

Malladi, Ram K. ;

Douglas, Kenneth W. ;

Maher, Tracey ;

Guest, Julie ;

Hartlett, Laura ;

Fisher, Andrew J. ;

Child, Fiona ;

Scarisbrick, Julia J. .

BRITISH JOURNAL OF HAEMATOLOGY, 2017, 177 (02) :287-310

[2]

[Anonymous], 2018, DEATH PULM EMB REL E

[3] Extracorporeal photopheresis therapy in the management of steroid-refractory or steroid-dependent cutaneous chronic graft-versus-host disease after allogeneic stem cell transplantation:: feasibility and results [J].

Apisarnthanarax, N ;

Donato, M ;

Körbling, M ;

Couriel, D ;

Gajewski, J ;

Giralt, S ;

Khouri, I ;

Hosing, C ;

Champlin, R ;

Duvic, M ;

Anderlini, P .

BONE MARROW TRANSPLANTATION, 2003, 31 (06) :459-465

[4] Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4+CD25+GITR+Foxp3+CD62L+functional regulatory T-cells in patients with graft-versus-host disease [J].

Biagi, Ettore ;

Di Biaso, Iolanda ;

Leoni, Veronica ;

Gaipa, Giuseppe ;

Rossi, Vincenzo ;

Bugarin, Cristina ;

Renoldi, Giuliano ;

Parma, Matteo ;

Balduzzi, Adriana ;

Perseghin, Paolo ;

Biondi, Andrea .

TRANSPLANTATION, 2007, 84 (01) :31-39

[5] Extracorporeal photopheresis induces apoptosis in the lymphocytes of cutaneous T-cell lymphoma and graft-versus-host disease patients [J].

Bladon, J ;

Taylor, PC .

BRITISH JOURNAL OF HAEMATOLOGY, 1999, 107 (04) :707-711

[6] Technical comparison of four different extracorporeal photopheresis systems [J].

Brosig, Andreas ;

Haehnel, Viola ;

Orso, Evelyn ;

Wolff, Daniel ;

Holler, Ernst ;

Ahrens, Norbert .

TRANSFUSION, 2016, 56 (10) :2510-2519

[7] Extracorporeal photochemotherapy may improve outcome in children with acute GVHD [J].

Calore, E. ;

Calo, A. ;

Tridello, G. ;

Cesaro, S. ;

Pillon, M. ;

Varotto, S. ;

Gazzola, M. V. ;

Destro, R. ;

Marson, P. ;

Trentin, L. ;

Carli, M. ;

Messina, C. .

BONE MARROW TRANSPLANTATION, 2008, 42 (06) :421-425

[8] Efficacy and safety of one-day offline extracorporeal photopheresis schedule processing one total blood volume for treating patients with graft-versus-host disease [J].

Cid, Joan ;

Carbasse, Gloria ;

Suarez-Lledo, Maria ;

Moreno, David F. ;

Martinez, Carmen ;

Gutierrez-Garcia, Gonzalo ;

Fernandez-Aviles, Francesc ;

Rosinol, Laura ;

Giavedoni, Priscila ;

Mascaro, Jose M., Jr. ;

Agusti, Carles ;

Marin, Pedro ;

Rovira, Montserrat ;

Urbano-Ispizua, Alvaro ;

Lozano, Miquel .

TRANSFUSION, 2019, 59 (08) :2636-2642

[9] PHOTOSENSITIZATION OF EYE WITH METHOXSALEN .2. CHRONIC EFFECTS [J].

CLOUD, TM ;

GRIFFIN, AC ;

HAKIM, R .

ARCHIVES OF OPHTHALMOLOGY, 1961, 66 (05) :689-&

[10] Extracorporeal photochemotherapy for the treatment of steroid-resistant chronic GVHD [J].

Couriel, DR ;

Hosing, C ;

Saliba, R ;

Shpall, EJ ;

Anderlini, P ;

Rhodes, B ;

Smith, V ;

Khouri, I ;

Giralt, S ;

de Lima, M ;

Hsu, Y ;

Ghosh, S ;

Neumann, J ;

Andersson, B ;

Qazilbash, M ;

Hymes, S ;

Kim, S ;

Champlin, R ;

Donato, M .

BLOOD, 2006, 107 (08) :3074-3080

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