Regioselective lithium-halogen exchange and palladium-catalyzed cross-coupling reactions of 2,4-dihaloquinolines

被引：28

作者：

Comins, DL ^{[1
]}

Nolan, JM ^{[1
]}

Bori, ID ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 39期

基金：

美国国家科学基金会;

关键词：

lithium-halogen exchange; quinolines; cross-coupling; alpha-amino alkoxide;

D O I：

10.1016/j.tetlet.2005.07.137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lithium-halogen exchange of 2,4-dibromoquinolines proceeds regioselectively at C-4 and affords 4-substituted quinolines on quenching with electrophiles. Palladium-catalyzed cross-coupling reactions of 2-bromo-4-iodoquinoline provide 4-substituted 2-bromoquinoline derivatives. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6697 / 6699

页数：3

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