Crosstalk between different DNA repair pathways for DNA double strand break repairs

被引：28

作者：

Oh, Jung-Min ^{[1
]}

Myung, Kyungjae ^{[2
,3
]}

机构：

[1] Pusan Natl Univ, Sch Dent, Dent & Life Sci Inst, Dept Oral Biochem, Yangsan 50612, South Korea

[2] Inst Basic Sci IBS, Ctr Genom Integr, Ulsan 44919, South Korea

[3] Ulsan Natl Inst Sci & Technol, Dept Biomed Engn, Ulsan 44919, South Korea

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2022年 / 873卷

基金：

新加坡国家研究基金会;

关键词：

DNA double strand break repair; DNA end resection; NHEJ; HR; MMEJ; DEPENDENT PROTEIN-KINASE; MISMATCH-REPAIR; END RESECTION; CELL-CYCLE; HOMOLOGOUS-RECOMBINATION; POLYMERASE-LAMBDA; DAMAGE RESPONSE; IV COMPLEX; CANCER; KU;

D O I：

10.1016/j.mrgentox.2021.503438

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

DNA double strand breaks (DSBs) are the most threatening type of DNA lesions and must be repaired properly in order to inhibit severe diseases and cell death. There are four major repair pathways for DSBs: non-homologous end joining (NHEJ), homologous recombination (HR), single strand annealing (SSA) and alternative end joining (alt-EJ). Cells choose repair pathway depending on the cell cycle phase and the length of 3; end of the DNA when DSBs are generated. Blunt and short regions of the 5; or 3; overhang DNA are repaired by NHEJ, which uses direct ligation or limited resection processing of the broken DNA end. In contrast, HR, SSA and alt-EJ use the resected DNA generated by the MRN (MRE11-RAD50-NBS1) complex and C-terminal binding protein interacting protein (CtIP) activated during the S and G2 phases. Here, we review recent findings on each repair pathway and the choice of repair mechanism and highlight the role of mismatch repair (MMR) protein in HR.

引用

页数：6

共 89 条

[1] XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining [J].