Plasma amyloid beta predicts conversion to dementia in subjects with mild cognitive impairment: The BALTAZAR study

被引：24

作者：

Hanon, Olivier ^{[1
]}

Vidal, Jean-Sebastien ^{[1
]}

Lehmann, Sylvain ^{[2
]}

Bombois, Stephanie ^{[3
]}

Allinquant, Bernadette ^{[4
]}

Baret-Rose, Christiane ^{[4
]}

Treluyer, Jean-Marc ^{[5
]}

Abdoul, Hendy ^{[5
]}

Gele, Patrick ^{[6
]}

Delmaire, Christine ^{[3
]}

Blanc, Frederic ^{[7
]}

Mangin, Jean-Francois ^{[8
]}

Buee, Luc ^{[3
]}

Touchon, Jacques ^{[9
]}

Hugon, Jacques ^{[10
]}

Vellas, Bruno ^{[11
]}

Galbrun, Evelyne ^{[12
]}

Benetos, Athanase ^{[13
]}

Berrut, Gilles ^{[14
]}

Paillaud, Elena ^{[15
]}

Wallon, David ^{[16
,17
]}

Castelnovo, Giovanni ^{[18
]}

Volpe-Gillot, Lisette ^{[19
]}

Paccalin, Marc ^{[20
]}

Robert, Philippe ^{[21
]}

Godefroy, Olivier ^{[22
]}

Camus, Vincent ^{[23
]}

Belmin, Joel ^{[24
]}

Vandel, Pierre ^{[25
]}

Novella, Jean-Luc ^{[26
]}

Duron, Emmanuelle ^{[27
]}

Rigaud, Anne-Sophie ^{[1
]}

Schraen-Maschke, Susanna ^{[3
]}

Gabelle, Audrey ^{[9
]}

机构：

[1] Univ Paris, Hop Broca, AP HP, EA 4468,Memory Resource & Res Ctr Paris Broca Ile, Paris, France

[2] Univ Montpellier, CHU Montpellier, INSERM, LBPC, Montpellier, France

[3] Univ Lille, CHU Lille, INSERM, U1172,LiINCog,LiCEND,LabEx DISTALZ, Lille, France

[4] Univ Paris, Inst Psychiat & Neurosci, INSERM, UMRS 1266, Paris, France

[5] Univ Paris, Hop Necker, AP HP, Clin Res Unit, Paris, France

[6] Univ Lille, INSERM, CHU Lille, CRB CIC1403, Lille, France

[7] Univ Strasbourg, Hop Univ Strasbourg, Lab ICube, Equipe IMIS,FMTS,CNRS,CM2R,Pole Geriatrie, Strasbourg, France

[8] Univ Paris Saclay, CATI Multictr Neuroimaging Platform, CATI Neuroimagingcom, Neurospin,CEA,CNRS, Gif Sur Yvette, France

[9] Univ Montpellier, CHU Montpellier, Memory Res & Resources Ctr Montpellier,Inserm INM, Dept Neurol,Excellence Ctr Neurodegenerat Disorde, Montpellier, France

[10] Univ Paris, Grp Hosp St Louis Lariboisiere Fernand Widal, AP HP, Ctr Cognit Neurol, Paris, France

[11] Univ Toulouse III, CHU La Grave Casselardit, Memory Resource & Res Ctr Midi Pyrenees, Toulouse, France

[12] Sorbonne Univ, Ctr Hosp Dupuytren, AP HP, Dept Gerontol 2, Draveil, France

[13] Univ Lorraine, CHRU Nancy, Memory Resource & Res Ctr Lorraine, Vandoeuvre Les Nancy, France

[14] Univ Nantes, Memory Res Resource Ctr Nantes, CHU Nantes, Dept Clin Gerontol,EA Movement Interact Performan, Nantes, France

[15] Univ Paris, Hop Europeen Georges Pompidou, AP HP, Serv Geriatrie, Paris, France

[16] Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen,Dept Neurol, Rouen, France

[17] Normandie Univ, UNIROUEN, Inserm U1245, CNR MAJ,Normandy Ctr Genom & Personalized Med,CIC, Rouen, France

[18] CHU Nimes, Neurol Dept, Hop Caremeau, Nimes, France

[19] Hop Leopold Bellan, Serv Neuro Psycho Geriatrie, Memory Clin, Paris, France

[20] CHU Poitiers, Memory Resource & Res Ctr Poitiers, Poitiers, France

[21] Univ Cote Azur, CHU Nice, CoBTek Lab, Memory Res Resource Ctr Nice, Nice, France

[22] CHU Amiens Picardie, Memory Resource & Res Ctr Amiens Picardie, Amiens, France

[23] Univ Francois Rabelais Tours, UMR Inserm U1253, CHRU Tours, Tours, France

[24] Sorbonne Univ, Hop Univ Pitie Salpetriere Charles Foix, AP HP, Serv Geriatrie Ambulatoire, Paris, France

[25] Univ Bourgogne Franche Comte, CHU Besancon, Lab Rech Integrat Neurosci & Psychol Cognit, Memory Resource & Res Ctr Besancon Franche Comte, Besancon, France

[26] Univ Reims, CHU Reims, Memory Resource & Res Ctr Champagne Ardenne, EA 3797, Reims, France

[27] Univ Paris Saclay, Hop Paul Brousse, AP HP, Dept Geriatrie,Equipe MOODS,Inserm 1178, Villejuif, France

来源：

ALZHEIMERS & DEMENTIA | 2022年 / 18卷 / 12期

关键词：

Alzheimer's disease; amyloid beta protein; cerebrospinal fluid; major neurocognitive disorder; mild cognitive impairment; minor neurocognitive disorder; plasma biomarkers; prognosis; ALZHEIMERS ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; RISK; DISEASE; INDIVIDUALS; PROGRESSION; BIOMARKERS; PRECURSOR; RATIO;

D O I：

10.1002/alz.12613

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Blood-based biomarkers are the next challenge for Alzheimer's disease (AD) diagnosis and prognosis. Methods Mild cognitive impairment (MCI) participants (N = 485) of the BALTAZAR study, a large-scale longitudinal multicenter cohort, were followed-up for 3 years. A total of 165 of them converted to dementia (95% AD). Associations of conversion and plasma amyloid beta (A beta)(1-42), A beta(1-40), A beta(1-42)/A beta(1-40) ratio were analyzed with logistic and Cox models. Results Converters to dementia had lower level of plasma A beta(1-42) (37.1 pg/mL [12.5] vs. 39.2 [11.1] , P value = .03) and lower A beta(1-42)/A beta(1-40) ratio than non-converters (0.148 [0.125] vs. 0.154 [0.076], P value = .02). MCI participants in the highest quartile of A beta(1-42)/A beta(1-40) ratio (>0.169) had a significant lower risk of conversion (hazard ratio adjusted for age, sex, education, apolipoprotein E epsilon 4, hippocampus atrophy = 0.52 (95% confidence interval [0.31-0.86], P value = .01). Discussion In this large cohort of MCI subjects we identified a threshold for plasma A beta(1-42)/A beta(1-40) ratio that may detect patients with a low risk of conversion to dementia within 3 years.

引用

页码：2537 / 2550

页数：14

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