In response to "Guided Imagery and Memory" by K. D. Arbuthnott, D. W. Arbuthnott, & L. Rossiter (2001), C. Z. Enns (2001) and C. A. Courtois (2001) elaborated on implications for the use of guided imagery techniques in psychotherapy, particularly for the treatment of trauma. In general, the authors endorse these elaborations and the practice guidelines recommended by the American Psychological Association task force for working with clients who may have experienced delayed memories for child abuse. However, they disagree with statements about the limited utility of laboratory research to inform clinical practice and discuss what they consider to be a more productive rapprochement between laboratory and clinical research. As an example of how practice guidelines can evolve with developing knowledge from laboratory studies, the authors discuss emerging evidence that is relevant to the mechanisms underlying guided imagery misattributions, which may significantly influence the caution necessary when using realistic imagery in psychotherapeutic treatment.