Androgen Deficiency in Aging and Metabolically Challenged Men

被引：24

作者：

Shelton, Jeremy B. ^{[1
]}

Rajfer, Jacob ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, Los Angeles, CA 90095 USA

[2] Harbor UCLA Med Ctr, Div Urol, Torrance, CA 90509 USA

来源：

UROLOGIC CLINICS OF NORTH AMERICA | 2012年 / 39卷 / 01期

关键词：

Androgen deficiency; Late-onset hypogonadism; Elderly; Metabolic syndrome; ENDOGENOUS SEX-HORMONES; LOW FREE TESTOSTERONE; QUALITY-OF-LIFE; BONE-MINERAL DENSITY; CORONARY-ARTERY-DISEASE; SERUM-FREE TESTOSTERONE; LATE-ONSET HYPOGONADISM; SKELETAL-MUSCLE MASS; OLDER MEN; ELDERLY-MEN;

D O I：

10.1016/j.ucl.2011.09.007

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Androgen deficiency in aging men is common, and the potential sequelae are numerous. In addition to low libido, erectile dysfunction, decreased bone density, depressed mood, and decline in cognition, studies suggest strong correlations between low testosterone, obesity, and the metabolic syndrome. Because causation and its directionality remain uncertain, the functional and cardiovascular risks associated with androgen deficiency have led to intense investigation of testosterone replacement therapy in older men. Although promising, evidence for definitive benefit or detriment is not conclusive, and treatment of late-onset hypogonadism is complicated.

引用

页码：63 / +

页数：14