Stem cell-based therapy: Improving myocardial cell delivery

被引：33
作者：
Feyen, Dries A. M. [1 ,2 ]
Gaetani, Roberto [1 ,3 ,4 ]
Doevendans, Pieter A. [1 ,2 ,5 ]
Sluijter, Joost P. G. [1 ,2 ,5 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Cardiol, Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, UMC Utrecht Regenerat Med Ctr, Utrecht, Netherlands
[3] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Sanford Consortium Regenerat Med, La Jolla, CA 92093 USA
[5] Netherlands Heart Inst, Utrecht, Netherlands
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 106卷
关键词：
Cell therapy; Progenitor cell; Stem cell; Cell retention; Myocardial repair; CARDIAC PROGENITOR CELLS; SKELETAL MYOBLAST TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; ADIPOSE-TISSUE; ISCHEMIC-HEART; INFARCTED HEART; INTRACORONARY INFUSION; ALGINATE MICROSPHERES; CARDIOMYOCYTE GRAFTS; VENTRICULAR-FUNCTION;
D O I：
10.1016/j.addr.2016.04.023
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Stem cell-based therapies form an exciting new class of medicine that attempt to provide the body with the building blocks required for the reconstruction of damaged organs. However, delivering cells to the correct location, while preserving their integrity and functional properties, is a complex undertaking. These challenges have led to the development of a highly dynamic interdisciplinary research field, wherein medical, biological, and chemical sciences have collaborated to develop strategies to overcome the physiological barriers imposed on the cellular therapeutics. In this respect, improving the acute retention and subsequent survival of stem cells is key to effectively increase the effect of the therapy, while proper tissue integration is imperative for stem cells to functionally replace lost cells in damaged organs. In this review, we will use the heart as an example to highlight the current knowledge of therapeutic stem cell utilization, the existing pitfalls and limitations, and the approaches that have been developed to overcome them. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：104 / 115
页数：12
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