A palladium-catalyzed route for α-alkylation of ketones by primary alcohols

被引：109
|
作者：
Cho, CS [1 ]
机构：
[1] Kyungpook Natl Univ, Ind Technol Res Inst, Taegu 702701, South Korea
来源：
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2005年 / 240卷 / 1-2期
关键词：
alpha-alkylation; hydrogen acceptor; ketoncs; palladium catalysts; primary alcohols;
D O I：
10.1016/j.molcata.2005.06.043
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Ketones react with primary alcohols in dioxane at 100 degrees C in the presence of a catalytic amount of Pd/C and KOH along with 1-decene as a sacrificial hydrogen acceptor to give the corresponding coupled ketones in moderate to good yields. The catalytic pathway seems to be proceeded via a sequence involving initial oxidation of primary alcohols to aldehydes, cross aldol condensation, and regioselective reduction. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：55 / 60
页数：6
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