Molecularly targeted agents: Their promise as cancer chemopreventive interventions

被引：26
作者：
Thiery-Vuillemin, A
Nguyen, T
Pivot, X
Spano, JP
Dufresnne, A
Soria, JC
机构：
[1] Inst Gustave Roussy, Dept Med, F-94805 Villejuif, France
[2] CHU J Minjoz Besancon, Dept Med Oncol, Besancon, France
[3] Serv Oncol Med Pitie Salpetriere, Paris, France
来源：
EUROPEAN JOURNAL OF CANCER | 2005年 / 41卷 / 13期
关键词：
chemoprevention; trials; targeted agents;
D O I：
10.1016/j.ejca.2005.06.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Molecular medicine has fully entered in to the oncology arena. The development of targeted therapies is one of the major ongoing efforts in cancer treatment. Targeted therapy refers to treatment strategies directed against molecular targets considered to be involved in neoplastic transformation. Such molecularly targeted agents (MTA) are currently under study in all treatment settings including that of chemoprevention, defined as the use of natural or synthetic agents to interrupt the carcinogenic process, to nip tumours in the bud. This review article aims to provide a general overview of the potential use of some of these MTA in the chemoprevention setting. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2003 / 2015
页数：13
相关论文
共 164 条
[1]   The proteasome: structure, function, and role in the cell [J].
Adams, J .
CANCER TREATMENT REVIEWS, 2003, 29 :3-9
[2]  
Aizawa K, 1999, INT J ONCOL, V14, P85
[3]  
Akalin A, 2001, CANCER RES, V61, P4791
[4]   Mechanism of activation of protein kinase B by insulin and IGF-1 [J].
Alessi, DR ;
Andjelkovic, M ;
Caudwell, B ;
Cron, P ;
Morrice, N ;
Cohen, P ;
Hemmings, BA .
EMBO JOURNAL, 1996, 15 (23) :6541-6551
[5]   Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity [J].
Ali, IU ;
Schriml, LM ;
Dean, M .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (22) :1922-1932
[6]  
Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group, 1994, N Engl J Med, V330, P1029, DOI 10.1056/NEJM199404143301501
[7]   Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01 [J].
Amornphimoltham, P ;
Sriuranpong, V ;
Patel, V ;
Benavides, F ;
Conti, CJ ;
Sauk, J ;
Sausville, EA ;
Molinolo, AA ;
Gutkind, JS .
CLINICAL CANCER RESEARCH, 2004, 10 (12) :4029-4037
[8]  
ANDRE C, 1992, ONCOGENE, V7, P685
[9]   A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt [J].
Aoki, M ;
Blazek, E ;
Vogt, PK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (01) :136-141
[10]  
Aotake T, 1999, CLIN CANCER RES, V5, P135
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