Structural and biophysical insight into cholesteryl ester-transfer protein

被引：11
|
作者：
Hall, Justin [1 ]
Qiu, Xiayang [1 ]
机构：
[1] Pfizer Res & Dev, Groton, CT 06430 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2011年 / 39卷
关键词：
cardiovascular disease (CVD); cholesteryl ester-transfer protein (CETP); neutral lipid; phospholipid; triacylglycerol (TAG); CORONARY-HEART-DISEASE; HIGH-DENSITY-LIPOPROTEINS; APOLIPOPROTEIN-A-I; NEUTRALIZING MONOCLONAL-ANTIBODY; PERMEABILITY-INCREASING PROTEIN; INTIMA-MEDIA THICKNESS; HUMAN-PLASMA; CRYSTAL-STRUCTURE; CARDIOVASCULAR-DISEASE; THERAPEUTIC TARGET;
D O I：
10.1042/BST0391000
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data.
引用
收藏
页码：1000 / 1005
页数：6
相关论文
共 50 条
  • [31] Anacetrapib, a cholesteryl ester transfer protein inhibitor
    Hooper, Amanda J.
    Burnett, John R.
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2012, 21 (01) : 103 - 109
  • [32] Cholesteryl ester transfer protein and hyperalphalipoproteinemia in Caucasians
    van der Steeg, Wim A.
    Hovingh, G. Kees
    Klerkx, Anke H. E. M.
    Hutten, Barbara A.
    Nootenboom, Inge C.
    Levels, Johannes H. M.
    van Tol, Arie
    Dallinga-Thie, Gees M.
    Zwinderman, Aeilko H.
    Kastelein, John J. P.
    Kuivenhoven, Jan Albert
    JOURNAL OF LIPID RESEARCH, 2007, 48 (03) : 674 - 682
  • [33] CELLULAR PROCESSING OF CHOLESTERYL ESTER TRANSFER PROTEIN
    TALL, A
    SWENSON, T
    SIMMONS, J
    BISGAIER, C
    HESLER, C
    CIRCULATION, 1987, 76 (04) : 415 - 415
  • [34] Cholesteryl ester transfer protein: Friend or foe?
    Fielding, CJ
    Havel, RJ
    JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (12): : 2687 - 2688
  • [35] Crystal Structure of Cholesteryl Ester Transfer Protein
    Qiu, Xiayang
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 : C638 - C638
  • [36] CELLULAR PROCESSING OF CHOLESTERYL ESTER TRANSFER PROTEIN
    TALL, A
    SWENSON, T
    SIMMONS, J
    BISGAIER, C
    HESLER, C
    ARTERIOSCLEROSIS, 1987, 7 (05): : A537 - A537
  • [37] Cholesteryl ester transfer protein and its inhibitors
    Shrestha, Sudichhya
    Wu, Ben J.
    Guiney, Liam
    Barter, Philip J.
    Rye, Kerry-Anne
    JOURNAL OF LIPID RESEARCH, 2018, 59 (05) : 772 - 783
  • [38] Cholesteryl ester transfer protein and its inhibition
    Weber, Olaf
    Bischoff, Hilmar
    Schmeck, Carsten
    Boettcher, Michael-Friedrich
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2010, 67 (18) : 3139 - 3149
  • [39] Is there a need for cholesteryl ester transfer protein inhibition?
    Parini, P
    Rudel, LL
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (03) : 374 - 375
  • [40] Cholesteryl ester transfer protein in metabolic syndrome
    Sandhofer, Anton
    Kaser, Susanne
    Ritsch, Andreas
    Laimer, Markus
    Engl, Julia
    Paulweber, Bernhard
    Patsch, Josef R.
    Ebenbichler, Christoph F.
    OBESITY, 2006, 14 (05) : 812 - 818
12345