Structural and biophysical insight into cholesteryl ester-transfer protein

被引：11
|
作者：
Hall, Justin [1 ]
Qiu, Xiayang [1 ]
机构：
[1] Pfizer Res & Dev, Groton, CT 06430 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2011年 / 39卷
关键词：
cardiovascular disease (CVD); cholesteryl ester-transfer protein (CETP); neutral lipid; phospholipid; triacylglycerol (TAG); CORONARY-HEART-DISEASE; HIGH-DENSITY-LIPOPROTEINS; APOLIPOPROTEIN-A-I; NEUTRALIZING MONOCLONAL-ANTIBODY; PERMEABILITY-INCREASING PROTEIN; INTIMA-MEDIA THICKNESS; HUMAN-PLASMA; CRYSTAL-STRUCTURE; CARDIOVASCULAR-DISEASE; THERAPEUTIC TARGET;
D O I：
10.1042/BST0391000
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data.
引用
收藏
页码：1000 / 1005
页数：6
相关论文
共 50 条
  • [1] Association of cholesteryl ester-transfer protein (CETP) polymorphisms with HDL levels in Chinese obesity subjects
    Liang, X. Q.
    Ruan, X.
    Shi, Y.
    Lindpaintner, K.
    Liu, L.
    Zhang, J.
    Wang, X.
    JOURNAL OF HYPERTENSION, 2008, 26 : S143 - S143
  • [2] The Taq1B-variant in the cholesteryl ester-transfer protein gene and the risk of metabolic syndrome
    Sandhofer, Anton
    Tatarczyk, Tobias
    Laimer, Markus
    Ritsch, Andreas
    Kaser, Susanne
    Paulweber, Bernhard
    Ebenbichler, Christoph F.
    Patsch, Josef R.
    OBESITY, 2008, 16 (04) : 919 - 922
  • [3] Cholesteryl Ester Transfer Protein Penetrates Lipoproteins For Cholesteryl Ester Transfer
    Ren, Gang
    Zhang, Shengli
    Cavigiolio, Giorgio
    Lei, Dongsheng
    Oda, Michael
    Weisgraber, Karl H.
    Rye, Kerry-Anne
    Pownall, Henry J.
    Qiu, Xiayang
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 36A - 36A
  • [4] Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein
    Zhang, Lei
    Yan, Feng
    Zhang, Shengli
    Lei, Dongsheng
    Charles, M. Arthur
    Cavigiolio, Giorgio
    Oda, Michael
    Krauss, Ronald M.
    Weisgraber, Karl H.
    Rye, Kerry-Anne
    Pownall, Henry J.
    Qiu, Xiayang
    Ren, Gang
    NATURE CHEMICAL BIOLOGY, 2012, 8 (04) : 342 - 349
  • [5] Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein
    Lei Zhang
    Feng Yan
    Shengli Zhang
    Dongsheng Lei
    M Arthur Charles
    Giorgio Cavigiolio
    Michael Oda
    Ronald M Krauss
    Karl H Weisgraber
    Kerry-Anne Rye
    Henry J Pownall
    Xiayang Qiu
    Gang Ren
    Nature Chemical Biology, 2012, 8 (4) : 342 - 349
  • [6] Cholesteryl Ester-Transfer Protein Inhibitors Stimulate Aldosterone Biosynthesis in Adipocytes through Nox-Dependent Processes
    Rios, Francisco J.
    Neves, Karla B.
    Cat, Aurelie Nguyen Dinh
    Even, Sarah
    Palacios, Roberto
    Montezano, Augusto C.
    Touyz, Rhian M.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2015, 353 (01): : 27 - 34
  • [7] Bound Phospholipids Assist Cholesteryl Ester Transfer in the Cholesteryl Ester Transfer Protein
    Keshavamurthy, Amrutha
    Revanasiddappa, Prasanna D.
    Dixit, Sneha M.
    Priyanka, Gandasi R.
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, 63 (10) : 3054 - 3067
  • [8] MECHANISM OF CHOLESTERYL ESTER TRANSFER MEDIATED BY PLASMA CHOLESTERYL ESTER TRANSFER PROTEIN
    SWENSON, TL
    BROCIA, RW
    TALL, A
    CIRCULATION, 1987, 76 (04) : 415 - 415
  • [9] CHOLESTERYL ESTER TRANSFER PROTEIN
    不详
    LANCET, 1991, 338 (8768): : 666 - 667
  • [10] ASSAY OF CHOLESTERYL ESTER TRANSFER ACTIVITY AND PURIFICATION OF A CHOLESTERYL ESTER TRANSFER PROTEIN
    OGAWA, Y
    FIELDING, CJ
    METHODS IN ENZYMOLOGY, 1985, 111 : 274 - 285
12345