A novel efficient and chemoselective method for the reduction of nitriles using the system silane/oxo-rhenium complexes

被引：49

作者：

Cabrita, Ivania ^{[1
]}

Fernandes, Ana C. ^{[1
]}

机构：

[1] Univ Tecn Lisboa, Inst Super Tecn, Ctr Quim Estrutural, P-1049001 Lisbon, Portugal

来源：

TETRAHEDRON | 2011年 / 67卷 / 42期

关键词：

Nitriles; Reduction; Primary amines; Silanes; Oxo-rhenium complexes; PRIMARY AMINES; ENANTIOSELECTIVE REDUCTION; CATALYTIC HYDROSILYLATION; HIGHLY EFFICIENT; SULFOXIDES; ALDEHYDES; HYDROGENATION; KETONES; AMIDES;

D O I：

10.1016/j.tet.2011.08.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work reports the reduction of nitriles to the corresponding primary amines with silanes catalyzed by oxo-rhenium complexes. The catalytic system PhSiH3/ReIO2(PPh3)(2) (10 mol %) reduced efficiently a series of nitriles in the presence of a wide range of functional groups such as -Cl, -F, -Br, -I, -CF3, -OCH3, -SCH3, -SO2CH3 and -NHTs. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：8183 / 8186

页数：4

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