Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters

被引：16

作者：

Chen, Hao ^{[1
,2
]}

He, Maomao ^{[1
,2
]}

Wang, Yaya ^{[1
,2
]}

Zhai, Linhui ^{[1
,2
]}

Cui, Yongbo ^{[1
,2
]}

Li, Yangyan ^{[1
,2
]}

Li, Yan ^{[3
]}

Zhou, Haibing ^{[1
,2
]}

Hong, Xuechuan ^{[1
,2
]}

Deng, Zixin ^{[1
,2
]}

机构：

[1] Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynthesis & Drug Discove, Wuhan 430071, Peoples R China

[2] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

来源：

GREEN CHEMISTRY | 2011年 / 13卷 / 10期

关键词：

NATIVE CHEMICAL LIGATION; CATALYZED DOUBLE CARBOHYDROAMINATION; AMIDE SYNTHESIS; MILD AMIDATION; ONE-POT; OXIDATIVE AMIDATION; GENERAL-SOLUTION; ALDEHYDES; ALCOHOLS; EFFICIENT;

D O I：

10.1039/c1gc15401j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters in the presence of bis(trimethylsilyl) acetamide (BSA) has been developed. This general method provides convenient access to N-protected peptides in good yields under mild conditions and demonstrates a high tolerance to functionality.

引用

页码：2723 / 2726

页数：4

共 67 条

[1]

Ali B.E., 2003, Appl. Organometal. Chem, V17, P921

[2] Catalytic Acylation of Amines with Aldehydes or Aldoximes [J].