123I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies

被引：61

作者：

Orimo, Satoshi ^{[1
]}

Yogo, Makiko ^{[2
]}

Nakamura, Tomohiko ^{[3
]}

Suzuki, Masahiko ^{[2
]}

Watanabe, Hirohisa ^{[4
]}

机构：

[1] Kanto Cent Hosp, Dept Neurol, Tokyo 1588531, Japan

[2] Jikei Univ, Sch Med, Katsushika Med Ctr, Dept Neurol, Tokyo, Japan

[3] Nagoya Univ, Grad Sch Med, Dept Neurol, Nagoya, Aichi 4648601, Japan

[4] Nagoya Univ, Brain & Mind Res Ctr, Nagoya, Aichi 4648601, Japan

来源：

AGEING RESEARCH REVIEWS | 2016年 / 30卷

关键词：

Meta-iodobenzylguanidine cardiac scintigraphy; Differential diagnosis; Parkinson's disease; Dementia with Lewy bodies; Neurodegenerative parkinsonism; I-123-MIBG MYOCARDIAL SCINTIGRAPHY; MULTIPLE-SYSTEM ATROPHY; LEWY BODY DISEASE; RECESSIVE JUVENILE PARKINSONISM; PURE AUTONOMIC FAILURE; SYMPATHETIC DENERVATION; DIFFERENTIAL-DIAGNOSIS; CLINICAL-FEATURES; DIABETIC-PATIENTS; EARLY-STAGE;

D O I：

10.1016/j.arr.2016.01.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiac meta-iodobenzylguanidine (MIBG) uptake on I-123-MIBG cardiac scintigraphy is reduced in patients with Lewy body disease such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pure autonomic failure, and has been reported to be useful for differentiating PD from other parkinsonian syndromes, as well as DLB from Alzheimer disease (AD). Postmortem studies have shown that the number of tyrosine hydroxylase (TH)-immunoreactive nerve fibers of the heart was decreased in pathologically-confirmed Lewy body disease, supporting the findings of reduced cardiac MIBG uptake in Lewy body diseases. Now, reduced cardiac MIBG uptake can be a potential biomarker for the presence of Lewy bodies in the nervous system. I-123-MIBG cardiac scintigraphy can allow us to determine the presence of Lewy bodies. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：122 / 133

页数：12

共 124 条

[1] Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system [J].