The interaction between bacteria and bile

被引:1326
作者
Begley, M
Gahan, CGM [1 ]
Hill, C
机构
[1] Natl Univ Ireland Univ Coll Cork, Dept Microbiol & Alimentary Pharmabiot Ctr, Cork, Ireland
[2] Natl Univ Ireland Univ Coll Cork, Sch Pharm, Cork, Ireland
关键词
bile salt hydrolase; gastrointestinal persistence; probiotic; stress; virulence;
D O I
10.1016/j.femsre.2004.09.003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Commensal and pathogenic microorganisms must resist the deleterious actions of bile in order to survive in the human gastrointestinal tract. Herein we review the current knowledge on the mechanisms by which Gram-positive and Gram-negative bacteria contend with bile stress. We describe the antimicrobial actions of bile, assess the variations in bile tolerance between bacterial genera and examine the interplay between bile stress and other stresses. The molecular mechanisms underlying bile tolerance are investigated and the relationship between bile and virulence is examined. Finally, the potential benefits of bile research are briefly discussed. (c) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:625 / 651
页数:27
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