Antimicrobial Effect of Chitosan Nanoparticles on Streptococcus mutans Biofilms

被引：169

作者：

de Paz, Luis E. Chavez ^{[1
]}

Resin, Anton ^{[2
]}

Howard, Kenneth A. ^{[2
]}

Sutherland, Duncan S. ^{[2
]}

Wejse, Peter L. ^{[3
]}

机构：

[1] Malmo Univ, Fac Odontol, Dept Oral Biol, SE-20506 Malmo, Sweden

[2] Aarhus Univ, Fac Sci, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus C, Denmark

[3] Arla Foods Amba, Global Ingredients R&D, Viby J, Denmark

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2011年 / 77卷 / 11期

关键词：

DENTAL PLAQUE; ACID TOLERANCE; ORAL BACTERIA; DELIVERY;

D O I：

10.1128/AEM.02941-10

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nanoparticle complexes were prepared from chitosans of various molecular weights (MW) and degrees of deacetylation (DD). The antimicrobial effect was assessed by the Live/Dead BacLight technique in conjunction with confocal scanning laser microscopy (CSLM) and image analysis. Nanocomplexes prepared from chitosans with high MW showed a low antimicrobial effect (20 to 25% of cells damaged), whereas those prepared from low-MW chitosans showed high antimicrobial effect (>95% of cells damaged).

引用

页码：3892 / 3895

页数：4

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