Centromeres: unique chromatin structures that drive chromosome segregation

被引：163

作者：

Verdaasdonk, Jolien S. ^{[1
]}

Bloom, Kerry ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

KINETOCHORE-MICROTUBULE ATTACHMENT; HISTONE H3 VARIANT; NUCLEOSOME CORE PARTICLE; E3 UBIQUITIN LIGASE; FISSION YEAST SCM3; CENP-A NUCLEOSOMES; MOLECULAR ARCHITECTURE; BI-ORIENTATION; HIR PROTEINS; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1038/nrm3107

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fidelity during chromosome segregation is essential to prevent aneuploidy. The proteins and chromatin at the centromere form a unique site for kinetochore attachment and allow the cell to sense and correct errors during chromosome segregation. Centromeric chromatin is characterized by distinct chromatin organization, epigenetics, centromere-associated proteins and histone variants. These include the histone H3 variant centromeric protein A (CENPA), the composition and deposition of which have been widely investigated. Studies have examined the structural and biophysical properties of the centromere and have suggested that the centromere is not simply a 'landing pad' for kinetochore formation, but has an essential role in mitosis by assembling and directing the organization of the kinetochore.

引用

页码：320 / 332

页数：13

共 177 条

[51] NUCLEOTIDE-SEQUENCE COMPARISONS AND FUNCTIONAL-ANALYSIS OF YEAST CENTROMERE DNAS [J].

FITZGERALDHAYES, M ;

CLARKE, L ;

CARBON, J .

CELL, 1982, 29 (01) :235-244

[52] Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeres [J].

Folco, Hernan Diego ;

Pidoux, Alison L. ;

Urano, Takeshi ;

Allshire, Robin C. .

SCIENCE, 2008, 319 (5859) :94-97

[53] Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP [J].

Foltz, Daniel R. ;

Jansen, Lars E. T. ;

Bailey, Aaron O. ;

Yates, John R., III ;

Bassett, Emily A. ;

Wood, Stacey ;

Black, Ben E. ;

Cleveland, Don W. .

CELL, 2009, 137 (03) :472-484

[54] The human CENP-A centromeric nucleosome-associated complex [J].

Foltz, DR ;

Jansen, LET ;

Black, BE ;

Bailey, AO ;

Yates, JR ;

Cleveland, DW .

NATURE CELL BIOLOGY, 2006, 8 (05) :458-U77

[55] Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer [J].

Fraga, MF ;

Ballestar, E ;

Villar-Garea, A ;

Boix-Chornet, M ;

Espada, J ;

Schotta, G ;

Bonaldi, T ;

Haydon, C ;

Ropero, S ;

Petrie, K ;

Iyer, NG ;

Pérez-Rosado, A ;

Calvo, E ;

Lopez, JA ;

Cano, A ;

Calasanz, MJ ;

Colomer, D ;

Piris, MA ;

Ahn, N ;

Imhof, A ;

Caldas, C ;

Jenuwein, T ;

Esteller, M .

NATURE GENETICS, 2005, 37 (04) :391-400

[56] Priming of centromere for CENP-A recruitment by human hMis18α, hMis18β, and M18BP1 [J].

Fujita, Yohta ;

Hayashi, Takeshi ;

Kiyomitsu, Tomomi ;

Toyoda, Yusuke ;

Kokubu, Aya ;

Obuse, Chikashi ;

Yanagida, Mitsuhiro .

DEVELOPMENTAL CELL, 2007, 12 (01) :17-30

[57] Creation and characterization of temperature-sensitive CENP-C mutants in vertebrate cells [J].

Fukagawa, T ;

Regnier, V ;

Ikemura, T .

NUCLEIC ACIDS RESEARCH, 2001, 29 (18) :3796-3803

[58]

Fukagawa Tatsuo, 2009, P133, DOI 10.1007/978-0-387-69076-6_6

[59] Centromere identity is specified by a single centromeric nucleosome in budding yeast [J].

Furuyama, Suzanne ;

Biggins, Sue .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (37) :14706-14711

[60] Chaperone-mediated assembly of centromeric chromatin in vitro [J].

Furuyama, T ;

Dalal, Y ;

Henikoff, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (16) :6172-6177

← 1 2 3 4 5 6 7 8 9 10 →