Centromeres: unique chromatin structures that drive chromosome segregation

被引：163

作者：

Verdaasdonk, Jolien S. ^{[1
]}

Bloom, Kerry ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

KINETOCHORE-MICROTUBULE ATTACHMENT; HISTONE H3 VARIANT; NUCLEOSOME CORE PARTICLE; E3 UBIQUITIN LIGASE; FISSION YEAST SCM3; CENP-A NUCLEOSOMES; MOLECULAR ARCHITECTURE; BI-ORIENTATION; HIR PROTEINS; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1038/nrm3107

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fidelity during chromosome segregation is essential to prevent aneuploidy. The proteins and chromatin at the centromere form a unique site for kinetochore attachment and allow the cell to sense and correct errors during chromosome segregation. Centromeric chromatin is characterized by distinct chromatin organization, epigenetics, centromere-associated proteins and histone variants. These include the histone H3 variant centromeric protein A (CENPA), the composition and deposition of which have been widely investigated. Studies have examined the structural and biophysical properties of the centromere and have suggested that the centromere is not simply a 'landing pad' for kinetochore formation, but has an essential role in mitosis by assembling and directing the organization of the kinetochore.

引用

页码：320 / 332

页数：13

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