Mixed cortical adenoma and composite pheochromocytoma-ganglioneuroma: an unusual corticomedullary tumor of the adrenal gland

被引:29
作者
Lau, Sean K. [1 ]
Chu, Peiguo G. [1 ]
Weiss, Lawrence M. [1 ]
机构
[1] City Hope Natl Med Ctr, Div Pathol, Duarte, CA 91010 USA
关键词
Adrenal gland; Corticomedullary tumor; Composite pheochromocytoma; CUSHINGS-SYNDROME; PATIENT; ASSOCIATION; FEATURES; BENIGN; ENTITY;
D O I
10.1016/j.anndiagpath.2010.02.005
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Adrenal neoplasms composed of more than one cell type and demonstrating a mixed histologic appearance are exceedingly rare. We report the clinical and pathologic features of a morphologically distinctive tumor of the adrenal gland composed of cortical, chromaffin, and neural cells. Histologically, the tumor consisted of intermixed areas of proliferating cortical cells resembling adrenal cortical adenoma, neoplastic chromaffin cells consistent with pheochromocytoma, and a ganglioneuromatous stroma. The presence of the cortical, medullary, and neural components within the tumor was confirmed by immunohistochemical studies. The present case serves to broaden the morphologic spectrum of mixed tumors that may be encountered in the adrenal gland. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:185 / 189
页数:5
相关论文
共 39 条
  • [11] COTESTA D, 2006, MINERVA ENDOCRINOL, V31, P18318
  • [12] Delèvaux I, 1998, PRESSE MED, V27, P1272
  • [13] Intraadrenal interactions in the regulation of adrenocortical steroidogenesis
    Ehrhart-Bornstein, M
    Hinson, JP
    Bornstein, SR
    Scherbaum, WA
    Vinson, GP
    [J]. ENDOCRINE REVIEWS, 1998, 19 (02) : 101 - 143
  • [14] Hu Wei-Lie, 2002, Di Yi Jun Yi Da Xue Xue Bao, V22, P1145
  • [15] KHAN AN, 2009, ENDOCR PRACT, P1
  • [16] Neurofibromin and NF1 gene analysis in composite pheochromocytoma and tumors associated with von Recklinghausen's disease
    Kimura, N
    Watanabe, T
    Fukase, M
    Wakita, A
    Noshiro, T
    Kimura, I
    [J]. MODERN PATHOLOGY, 2002, 15 (03) : 183 - 188
  • [17] Kimura Noriko, 1991, Endocr Pathol, V2, P139, DOI 10.1007/BF02915454
  • [18] Composite pheochromocytoma-ganglioneuroma of the adrenal gland: An uncommon entity with distinctive clinicopathologic features
    Lam, KY
    Lo, CY
    [J]. ENDOCRINE PATHOLOGY, 1999, 10 (04) : 343 - 352
  • [19] Lamovec J, 1998, ARCH PATHOL LAB MED, V122, P63
  • [20] Phaeochromocytoma and mixed corticomedullary tumour - a rare cause of Cushing's syndrome and labile hypertension in a primigravid woman postpartum
    Lee, P.
    Bradbury, R. A.
    Sy, J.
    Hughes, L.
    Wong, L.
    Falk, G.
    Chen, R.
    [J]. CLINICAL ENDOCRINOLOGY, 2008, 68 (03) : 492 - 494