Potentiation of BCNU cytotoxicity by molecules targeting abasic lesions in DNA

被引：18

作者：

Alarcon, K

Demeunynck, M

Lhomme, J

Carrez, D

Croisy, A

机构：

[1] Univ Grenoble 1, Etud Dynam & Struct Select Lab, CNRS, UMR 5616, F-38041 Grenoble 9, France

[2] Ctr Univ, Lab Raymond Latarjet, Inst Curie Rech, INSERM,U350, F-91405 Orsay, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0968-0896(01)00097-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the synthesis, DNA binding measurements and pharmacological properties of a series of new heterodimeric molecules, in which a 2,6-diaminopurine is linked to a 9-aminoacridine chromophore. The linking chain contains a central N,N'-disubstituted guanidine, connected to the two chromophores by polymethylenic units of variable length. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1901 / 1910

页数：10

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