Significance of myofibroblasts in oral squamous cell carcinoma

被引：40

作者：

Thode, Christenze ^{[1
]}

Jorgensen, Trine G. ^{[1
]}

Dabelsteen, Erik ^{[1
]}

Mackenzie, Ian ^{[2
]}

Dabelsteen, Sally ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Hlth Sci, Sch Dent, Copenhagen, Denmark

[2] Barts & London Queen Marys Sch Med & Dent, Ctr Cutaneous Res, London, England

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2011年 / 40卷 / 03期

关键词：

leukoplakia; oral cancer; CANCER-ASSOCIATED FIBROBLASTS; EPITHELIAL-MESENCHYMAL TRANSITION; PLASMINOGEN-ACTIVATOR INHIBITOR-1; TUMOR MICROENVIRONMENT; STROMAL MYOFIBROBLASTS; UROKINASE RECEPTOR; SKIN FIBROBLASTS; BREAST-CANCER; DIFFERENTIATION; INVASION;

D O I：

10.1111/j.1600-0714.2010.00999.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are alpha-smooth muscle actin-positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis.

引用

页码：201 / 207

页数：7

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