The management of metastatic neck nodes following induction chemotherapy in N2/3 classification hypopharyngeal carcinoma

被引：2
作者：
Li, Feiran [1 ]
Hsueh, Chiyao [1 ]
Gong, Hongli [1 ]
Zhu, Yi [2 ]
Tao, Lei [1 ]
Zhou, Liang [1 ]
Wang, Shengzi [2 ]
Zhang, Ming [1 ]
机构：
[1] Fudan Univ, Eye & ENT Hosp, Dept Otorhinolaryngol, 83 Fen Yang Rd, Shanghai, Peoples R China
[2] Fudan Univ, Eye & ENT Hosp, Dept Radiat Oncol, 83 Fen Yang Rd, Shanghai, Peoples R China
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2022年 / 44卷 / 09期
基金：
上海市自然科学基金;
关键词：
chemoselection; hypopharyngeal carcinoma; induction chemotherapy; neck dissection; neck nodes metastasis; ADVANCED HEAD; DEFINITIVE CHEMORADIOTHERAPY; DISSECTION; CANCER; RADIATION; CHEMORADIATION; PRESERVATION; RECURRENCE; LARYNGEAL; THERAPY;
D O I：
10.1002/hed.27106
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background For patients with less chemosensitive neck nodes, poor prognosis after chemoradiotherapy (CRT) could be predicted and neck dissection is needed. Methods Ninety-two N2/3 hypopharyngeal carcinoma patients were retrospectively studied. According to response after induction chemotherapy (ICT), patients were treated with neck dissection followed by concurrent CRT (CCRT) (group 1), surgery plus postoperative CRT (group 2), or CCRT for primary and regional sites (group 3). Results Overall survival and disease-free survival rates of group 1 were significantly higher than group 2 (p = 0.038, p = 0.031) and group 3 (both p = 0.018). Regional control rate of group 1 was significantly higher than group 3 (p = 0.041). There were no significant differences between groups 1 and 2 regarding local and regional control (p = 0.746, p = 0.302). Conclusions Neck dissection followed by CCRT is the best choice for patients with responsive primary but nonresponsive nodes.
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收藏
页码：2009 / 2017
页数：9
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