Unfavourable blood pressure and LDL-cholesterol levels in obese non-diabetic individuals

被引:2
|
作者
Wolffenbuttel, B. H. R. [1 ]
Slagter, S. N. [1 ]
van Waateringe, R. P. [1 ]
van Beek, A. P. [1 ]
van Vliet-Ostaptchouk, J. V. [1 ]
van der Klauw, M. M. [1 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands
来源
NETHERLANDS JOURNAL OF MEDICINE | 2017年 / 75卷 / 09期
关键词
Blood pressure; lipids; obesity; epidemiology; treatment; BODY-MASS INDEX; RISK-FACTORS; CARDIOVASCULAR-DISEASE; HYPERTENSION MANAGEMENT; PRIMARY-CARE; PREVALENCE; PREVENTION; MORTALITY; COMMUNITY; EUROPE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Early diagnosis and treatment of high blood pressure (BP) and cholesterol is important to reduce cardiovascular risk. We compared BP and LDL-cholesterol (LDL-C) as well as the quality of treatment between obese subjects and normal weight and overweight individuals. Methods: 87,648 participants of the Lifelines study were categorised according to obesity (normal weight/overweight/obesity) and age. Mean systolic BP and LDL-C were calculated depending on treatment, BMI, age and sex. Results: In all age groups, except those aged 70-80 years, women had a significantly lower BP than men. Use of BP-lowering medication did not result in BP levels comparable with non-users, except in those aged 70-80 years. Despite medication, the BP was insufficiently controlled in 20-50% of participants. BP was significantly higher in obese vs. normal weight and overweight individuals of all ages, but most apparently in men younger than 50 years. Mean LDL-C varied between 2.5-3.0 mmol/l. Despite higher statin use, obese participants had a higher LDL-C than those with a normal weight. Statins abolished the age-dependent LDL-C increase. Many participants did not achieve target LDL-C < 2.5 mmol/l. A small percentage of individuals treated with BP-lowering drugs were also using statins (overall 32% in men, 17% in women). Conclusion: Obese individuals, especially men younger than 50, have a higher BP and LDL-C compared with those with overweight and a normal weight. Use of BP-lowering drugs did not revert the BP back to levels normal for the specific age and BMI group, whereas statins abolished the age-related increase in LDL-C. These data suggest that more attention is needed for active screening and treatment of cardiovascular risk factors.
引用
收藏
页码:399 / 411
页数:13
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