The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

被引：72
作者：
Abel, M [1 ]
Hoenderop, J [1 ]
Bindels, R [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2005年 / 371卷 / 04期
关键词：
ECaC; kidney; intestine; active Ca2+ transport; vitamin D; estrogen; parathyroid hormone; channel (in)activation;
D O I：
10.1007/s00210-005-1021-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The epithelial Ca2+ channels TRPV5 and TRPV6 represent a new family of Ca2+ channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical Ca2+ entry mechanism in active Ca2+ transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active Ca2+ (re)absorption makes it a prime target for regulation to maintain Ca2+ balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial Ca2+ channels.
引用
收藏
页码：295 / 306
页数：12
相关论文
共 132 条
[1]   Decrease in kidney calbindin-D 28kDa as a possible mechanism mediating cyclosporine A- and FK-506-induced calciuria and tubular mineralization [J].
Aicher, L ;
Meier, G ;
Norcross, AJ ;
Jakubowski, J ;
Varela, MD ;
Cordier, A ;
Steiner, S .
BIOCHEMICAL PHARMACOLOGY, 1997, 53 (05) :723-731
[2]  
ASPLIN JR, 1996, KIDNEY, P1893
[3]   Stone prevention: why so little progress? [J].
Baumann, JM .
UROLOGICAL RESEARCH, 1998, 26 (02) :77-81
[4]   Physiological roles of axonal ankyrins in survival of premyelinated axons and localization of voltage-gated sodium channels [J].
Bennett, V ;
Lambert, S .
JOURNAL OF NEUROCYTOLOGY, 1999, 28 (4-5) :303-318
[5]  
BINDELS RJM, 1993, J EXP BIOL, V184, P89
[6]   Ca2+ dependence of the Ca2+selective TRPV6 channel [J].
Bödding, M ;
Flockerzi, V .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (35) :36546-36552
[7]   Ca2+-calmodulin regulates receptor-operated Ca2+ entry activity of TRPC6 in HEK-293 cells [J].
Boulay, G .
CELL CALCIUM, 2002, 32 (04) :201-207
[8]   Effects of excess PTH on nonclassical target organs [J].
Bro, S ;
Olgaard, K .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1997, 30 (05) :606-620
[9]   AN ANALYSIS OF INTESTINAL CALCIUM-TRANSPORT ACROSS THE RAT INTESTINE [J].
BRONNER, F ;
PANSU, D ;
STEIN, WD .
AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 250 (05) :G561-G569
[10]   Mechanisms of intestinal calcium absorption [J].
Bronner, F .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2003, 88 (02) :387-393
12345678910