MiR-125b-5p ameliorates hypoxia/reoxygenation-induced endothelial cell dysfunction and attenuates reduced uterine perfusion pressure-induced hypertension in pregnant rats via targeting BMF

被引：4

作者：

Zheng, Haoyu ^{[1
]}

Yu, Zhou ^{[1
]}

Wang, Hairong ^{[1
]}

Liu, Hongxue ^{[1
]}

Chen, Xiaoqin ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Obstet, Huaian, Jiangsu, Peoples R China

来源：

HYPERTENSION IN PREGNANCY | 2022年 / 41卷 / 02期

关键词：

miR-125b-5p; BMF; human placental microvascular endothelial cells; pregnancy-induced hypertension; MICRORNAS; INVOLVEMENT; MANAGEMENT; APOPTOSIS; RNAS;

D O I：

10.1080/10641955.2022.2036753

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background and Purpose MicroRNA-125b-5p (miR-125b-5p) is downregulated in patients with gestational hypertension signs. However, the role of miR-125b-5p in pregnancy-induced hypertension (PIH) remains unknown. Methods The human placental microvascular endothelial cells (HPMECs) have undergone hypoxia and reoxygenation (H/R) treatment to establish PIH cellular model. Rats were performed with reduced uterine perfusion pressure (RUPP) operation to establish PIH animal model. Results MiR-125b-5p promoted viability while inhibited the apoptosis of H/R-treated HPMECs by downregulating BMF. MiR-125b-5p alleviated hypertensive symptoms and improved pregnancy outcomes in RUPP rats. Conclusion MiR-125b-5p ameliorates H/R-induced HPMEC dysfunction and attenuates RUPP-induced hypertension in pregnant rats by downregulating BMF.

引用

页码：79 / 88

页数：10

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