Monodispersed gold nanorod-embedded silica particles as novel Raman labels for biosensing

被引：122

作者：

Wang, Chungang ^{[1
]}

Chen, Ying ^{[1
]}

Wang, Tingting ^{[1
]}

Ma, Zhanfang ^{[2
]}

Su, Zhongmin ^{[1
]}

机构：

[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

[2] Capital Normal Univ, Dept Chem, Beijing 100037, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2008年 / 18卷 / 02期

关键词：

D O I：

10.1002/adfm.200700503

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocompatible, photostable, and multiplexing-compatible surface-enhanced Raman spectroscopic tagging materials have been developed that are composed of gold nanorod (GNR)-embedded silica particles and organic Raman labels. GNR-embedded silica particles were prepared with different surface coverage by the assembly of GNRs on silica particles based on an electrostatic interaction and subsequent coating of silica with controllable thickness. This method allows the incorporation of various organic Raman labels to generate intense surface-enhanced Raman scattering (SERS) spectra. Furthermore, SERS-active particles are demonstrated as novel Raman tags for immunoassay. The results suggest SERS tags can be used for multiplex and ultrasensitive detection of biomolecules.

引用

页码：355 / 361

页数：7

共 38 条

[1] The use of nanocrystals in biological detection [J].

Alivisatos, P .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52

[2] Surface modification for enhancing antibody binding on polymer-based microfluidic device for enzyme-linked immunosorbent assay [J].

Bai, Yunling ;

Koh, Chee Guan ;

Boreman, Megan ;

Juang, Yi-Je ;

Tang, I-Ching ;

Lee, L. James ;

Yang, Shang-Tian .

LANGMUIR, 2006, 22 (22) :9458-9467

[3] Surface-enhanced Raman spectroscopy (SERS) for sub-micromolar detection of DNA/RNA mononucleotides [J].

Bell, Steven E. J. ;

Sirimuthu, Narayana M. S. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (49) :15580-15581

[4]

BONSNICK KA, 2003, J PHYS CHEM B, V106, P8096

[5] Surface-enhanced Raman scattering [J].

Campion, A ;

Kambhampati, P .

CHEMICAL SOCIETY REVIEWS, 1998, 27 (04) :241-250

[6] Raman dye-labeled nanoparticle probes for proteins [J].

Cao, YC ;

Jin, RC ;

Nam, JM ;

Thaxton, CS ;

Mirkin, CA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (48) :14676-14677

[7] Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection [J].

Cao, YWC ;

Jin, RC ;

Mirkin, CA .

SCIENCE, 2002, 297 (5586) :1536-1540

[8] Surface-enhanced Raman scattering of small molecules from silver-coated silicon nanopores [J].

Chan, S ;

Kwon, S ;

Koo, TW ;

Lee, LP ;

Berlin, AA .

ADVANCED MATERIALS, 2003, 15 (19) :1595-+

[9] Spectral encoding on gold nanorods doped in a silica sol-gel matrix and its application to high-density optical data storage [J].

Chon, James W. M. ;

Bullen, Craig ;

Zijlstra, Peter ;

Gu, Min .

ADVANCED FUNCTIONAL MATERIALS, 2007, 17 (06) :875-880

[10] Aligning an nanorods by using carbon nanotubes as templates [J].

Correa-Duarte, MA ;

Pérez-Juste, J ;

Sánchez-Iglesias, A ;

Giersig, M ;

Liz-Marzán, LM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (28) :4375-4378

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