Room-Temperature Gold-Catalysed Arylation of Heteroarenes: Complementarity to Palladium Catalysis

被引：56

作者：

Cresswell, Alexander J. ^{[1
]}

Lloyd-Jones, Guy C. ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, EaStCHEM, Joseph Black Bldg,West Mains Rd, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 36期

基金：

欧洲研究理事会;

关键词：

arylation; C-H functionalisation; gold catalysis; heteroarenes; silicon; C-H ARYLATION; SELECTIVE ARYLATION; INDOLES; ARENES; ARYL; BOND; FUNCTIONALIZATION; 2-PYRIDONES; ARYLSILANES; ACTIVATION;

D O I：

10.1002/chem.201602893

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tailoring of the pre-catalyst, the oxidant and the arylsilane enables the first room-temperature, gold-catalysed, innate C-H arylation of heteroarenes. Regioselectivity is consistently high and, in some cases, distinct from that reported with palladium catalysis. Tolerance to halides and boronic esters, in both the heteroarene and silane partners, provides orthogonality to Suzuki-Miyaura coupling.

引用

页码：12641 / 12645

页数：5

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