In Vitro BACE-1 Inhibitory Activity of Resveratrol Oligomers from the Seed Extract of Paeonia lactiflora

被引：42

作者：

Choi, Chun Whan ^{[1
,2
]}

Choi, Yeon Hee ^{[1
]}

Cha, Mi-Ran ^{[1
,2
]}

Kim, Young Sup ^{[1
]}

Yon, Gyu Hwan ^{[2
]}

Hong, Kyung Sik ^{[1
]}

Park, Woo-Kyu ^{[2
]}

Kim, Young Ho ^{[2
]}

Ryu, Shi Yong ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Taejon 305606, South Korea

[2] Chungnam Natl Univ, Coll Pharm, Taejon, South Korea

来源：

PLANTA MEDICA | 2011年 / 77卷 / 04期

关键词：

Paeonia lactiflora; Paeoniaceae; BACE-1; inhibitors; resveratrol oligomer; AMYLOID PRECURSOR PROTEIN; BETA-SECRETASE; VITIS-AMURENSIS; PAEONIFLORIN; CONSTITUENTS; DERIVATIVES; ROOTS;

D O I：

10.1055/s-0030-1250370

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new resveratrol oligomer (1) together with eight related components (2-9) were isolated from the seed extract of Paeonia lactiflora (Paeoniaceae) as active principles responsible for the inhibition of beta-site APP-cleaving enzyme 1 (BACE-1) in vitro. The chemical structure of 1 was established as (-)-7a, 8a-cis-e-viniferin with the aid of spectroscopic analyses including NOESY experiments. All isolated resveratrol oligomers (1-9) demonstrated significant inhibition on baculovirus-expressed BACE-1 in a dose-dependent manner, which was assessed by the FRET assay using Rh-EVNLDAEFK as a substrate in vitro.

引用

页码：374 / 376

页数：3

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