Epigenetic Regulation of the Wnt/β-Catenin Signaling Pathway in Cancer

被引：50
作者：
Sharma, Ankita [1 ]
Mir, Rafeeq [2 ]
Galande, Sanjeev [1 ,3 ]
机构：
[1] Indian Inst Sci Educ & Res, Dept Biol, Ctr Excellence Epigenet, Pune, Maharashtra, India
[2] Univ Kashmir, Ctr Interdisciplinary Res & Innovat, Srinagar, India
[3] Shiv Nadar Univ, Sch Nat Sci, Dept Life Sci, Greater Noida, India
来源：
FRONTIERS IN GENETICS | 2021年 / 12卷
关键词：
Wnt signaling; beta-catenin; YAP; epigenetics; cancer; therapeutics; EPITHELIAL-MESENCHYMAL-TRANSITION; PREDICTIVE CHROMATIN SIGNATURES; PROMOTES CELL-PROLIFERATION; ADENOMATOUS POLYPOSIS-COLI; TUMOR-SUPPRESSOR PROTEIN; INTESTINAL STEM-CELLS; LONG NONCODING RNAS; BETA-CATENIN; COLORECTAL-CANCER; BREAST-CANCER;
D O I：
10.3389/fgene.2021.681053
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Studies over the past four decades have elucidated the role of Wnt/beta-catenin mediated regulation in cell proliferation, differentiation and migration. These processes are fundamental to embryonic development, regeneration potential of tissues, as well as cancer initiation and progression. In this review, we focus on the epigenetic players which influence the Wnt/beta-catenin pathway via modulation of its components and coordinated regulation of the Wnt target genes. The role played by crosstalk with other signaling pathways mediating tumorigenesis is also elaborated. The Hippo/YAP pathway is particularly emphasized due to its extensive crosstalk via the Wnt destruction complex. Further, we highlight the recent advances in developing potential therapeutic interventions targeting the epigenetic machinery based on the characterization of these regulatory networks for effective treatment of various cancers and also for regenerative therapies.</p>
引用
收藏
页数：27
相关论文
共 338 条
[1]   miR-141 as potential suppressor of β-catenin in breast cancer [J].
Abedi, Nairi ;
Mohammadi-Yeganeh, Samira ;
Koochaki, Ameneh ;
Karami, Fariba ;
Paryan, Mahdi .
TUMOR BIOLOGY, 2015, 36 (12) :9895-9901
[2]   Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI [J].
Agarwal, Puneet ;
Zhang, Bin ;
Ho, Yinwei ;
Cook, Amy ;
Li, Ling ;
Mikhail, Fady M. ;
Wang, Youzhen ;
McLaughlin, Margaret E. ;
Bhatia, Ravi .
BLOOD, 2017, 129 (08) :1008-1020
[3]   Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer [J].
Ai, Lingbao ;
Tao, Qian ;
Zhong, Sheng ;
Fields, C. Robert ;
Kim, Wan-Ju ;
Lee, Michael W. ;
Cui, Yan ;
Brown, Kevin D. ;
Robertson, Keith D. .
CARCINOGENESIS, 2006, 27 (07) :1341-1348
[4]   Histone methyltransferases in cancer [J].
Albert, Mareike ;
Helin, Kristian .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2010, 21 (02) :209-220
[5]  
Albini S, 2019, TRANSL EPIGENET SER, V11, P47, DOI 10.1016/B978-0-12-814879-2.00003-0
[6]   The 'just-right' signaling model:: APC somatic mutations are selected based on a specific level of activation of the β-catenin signaling cascade [J].
Albuquerque, C ;
Breukel, C ;
van der Luijt, R ;
Fidalgo, P ;
Lage, P ;
Slors, FJM ;
Leitao, CN ;
Fodde, R ;
Smits, R .
HUMAN MOLECULAR GENETICS, 2002, 11 (13) :1549-1560
[7]   The molecular hallmarks of epigenetic control [J].
Allis, C. David ;
Jenuwein, Thomas .
NATURE REVIEWS GENETICS, 2016, 17 (08) :487-500
[8]   Epigenetic therapies in haematological malignancies: Searching for true targets [J].
Altucci, Lucia ;
Minucci, Saverio .
EUROPEAN JOURNAL OF CANCER, 2009, 45 (07) :1137-1145
[9]   Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/βcatenin signaling [J].
Amen, Melanie ;
Espinoza, Herbert M. ;
Cox, Carol ;
Liang, Xiaowen ;
Wang, Jianbo ;
Link, Todd M. E. ;
Brennan, Richard G. ;
Martin, James F. ;
Amendt, Brad A. .
NUCLEIC ACIDS RESEARCH, 2008, 36 (02) :462-476
[10]   A Systematic Screen for Micro-RNAs Regulating the Canonical Wnt Pathway [J].
Anton, Roman ;
Chatterjee, Sujash S. ;
Simundza, Julia ;
Cowin, Pamela ;
DasGupta, Ramanuj .
PLOS ONE, 2011, 6 (10)
12345678910