Base-mediated reactions of N-alkyl-O-acyl hydroxamic acids:: synthesis of 3-oxo-2,3-dihydro-4-isoxazole carboxylic ester derivatives

被引：9
|
作者：
Clark, AJ [1 ]
Patel, D
Broadhurst, MJ
机构：
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
[2] Roche Discovery Welwyn, Welwyn Garden City AL7 3AY, Herts, England
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 42期
关键词：
D O I：
10.1016/j.tetlet.2003.08.098
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of malonyl derived O-acyl hydroxamic acid derivatives 10a-h with the phosphazene super base P-2-t-Bu 7 gives 2,3-dihydro-4-isoxazole carboxylic ester derivatives 11a-h. The rate and yield of the reaction is dependent upon the O-acyl substituent. (C) 2003 Published by Elsevier Ltd.
引用
收藏
页码：7763 / 7765
页数：3
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