Signaling complexes of voltage-gated sodium and calcium channels

被引:106
作者
Catterall, William A. [1 ]
机构
[1] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA
关键词
Effector proteins; Anchoring proteins; Regulatory proteins; Ion channels; Synaptic transmission; DEPENDENT PROTEIN-KINASE; C-TERMINAL DOMAIN; G-BETA-GAMMA; RAT HIPPOCAMPAL-NEURONS; VISININ-LIKE PROTEIN-2; FULL-LENGTH FORM; 2 SIZE FORMS; CA2+ CHANNELS; N-TYPE; SKELETAL-MUSCLE;
D O I
10.1016/j.neulet.2010.08.085
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Membrane depolarization and intracellular Ca2+ transients generated by activation of voltage-gated Na+ and Ca2+ channels are local signals, which initiate physiological processes such as action potential conduction, synaptic transmission, and excitation-contraction coupling. Targeting of effector proteins and regulatory proteins to ion channels is an important mechanism to ensure speed, specificity, and precise regulation of signaling events in response to local stimuli. This article reviews experimental results showing that Na+ and Ca2+ channels form local signaling complexes, in which effector proteins, anchoring proteins, and regulatory proteins interact directly with ion channels. The intracellular domains of these channels serve as signaling platforms, mediating their participation in intracellular signaling processes. These protein-protein interactions are important for regulation of cellular plasticity through modulation of Na+ channel function in brain neurons, for short-term synaptic plasticity through modulation of presynaptic Ca(V)2 channels, and for the fight-or-flight response through regulation of postsynaptic Ca(V)1 channels in skeletal and cardiac muscle. These localized signaling complexes are essential for normal function and regulation of electrical excitability, synaptic transmission, and excitation-contraction coupling. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:107 / 116
页数:10
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