Risks to patients with severe chronic neutropenia exposed to nitrous oxide: A case study

Severe chronic neutropenia is caused by a variety of hematological, immunological, metabolic, and infectious diseases, Furthermore, the interaction between nitrous oxide and vitamin B-12 can produce morphologic and functional impairment of the bone marrow, We are reporting about a patient with Kostmann's syndrome (syn. "infantile genetic agranulocytosis", "congenital neutropenia"), a rare, congenital disease with impaired maturation of neutrophil precursors in the bone marrow. The risk of nitrous oxide for patients with severe chronic neutropenia is discussed in this case report.