The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

被引：447

作者：

Socala, Katarzyna ^{[1
]}

Doboszewska, Urszula ^{[1
]}

Szopa, Aleksandra ^{[2
]}

Serefko, Anna ^{[2
]}

Wlodarczyk, Marcin ^{[3
]}

Zielinska, Anna ^{[4
]}

Poleszak, Ewa ^{[2
]}

Fichna, Jakub ^{[4
]}

Wlaz, Piotr ^{[1
]}

机构：

[1] Marie Curie Sklodowska Univ, Inst Biol Sci, Dept Anim Physiol & Pharmacol, Akad 19, PL-20033 Lublin, Poland

[2] Med Univ Lublin, Chair & Dept Appl & Social Pharm, Lab Preclin Testing, Chodzki 1, PL-20093 Lublin, Poland

[3] Med Univ Lodz, Dept Gen & Colorectal Surg, Haller Sq 1, PL-90624 Lodz, Poland

[4] Med Univ Lodz, Fac Med, Dept Biochem, Mazowiecka 6-8, PL-92215 Lodz, Poland

来源：

PHARMACOLOGICAL RESEARCH | 2021年 / 172卷

关键词：

Microbiota-gut-brain axis; Neuropsychiatric disorders; Neurological diseases; Fecal microbiota transplantation; Probiotics; AUTISM SPECTRUM DISORDER; CHAIN FATTY-ACIDS; MAJOR DEPRESSIVE DISORDER; ANXIETY-LIKE BEHAVIOR; LACTOBACILLUS-HELVETICUS R0052; BIFIDOBACTERIUM-LONGUM R0175; CHRONIC-FATIGUE-SYNDROME; PARKINSONS-DISEASE; FECAL MICROBIOTA; GASTROINTESTINAL SYMPTOMS;

D O I：

10.1016/j.phrs.2021.105840

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional communication between the gut and the brain suggesting that the gut microbes may shape neural development, modulate neurotransmission and affect behavior, and thereby contribute to the pathogenesis and/or progression of many neurodevelopmental, neuropsychiatric, and neurological conditions. This review summarizes recent data on the role of microbiota-gut-brain axis in the pathophysiology of neuropsychiatric and neurological disorders including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, and epilepsy. Also, the involvement of microbiota in gut disorders co-existing with neuropsychiatric conditions is highlighted. We discuss data from both in vivo preclinical experiments and clinical reports including: (1) studies in germ-free animals, (2) studies exploring the gut microbiota composition in animal models of diseases or in humans, (3) studies evaluating the effects of probiotic, prebiotic or antibiotic treatment as well as (4) the effects of fecal microbiota transplantation.

引用

页数：38

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