Dynamic kinetic resolution catalyzed by Ir axially chiral phosphine catalyst:: Asymmetric synthesis of anti aromatic β-hydroxy-α-amino acid esters

被引：72

作者：

Makino, K ^{[1
]}

Hiroki, Y ^{[1
]}

Hamada, Y ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 16期

关键词：

D O I：

10.1021/ja0432113

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The anti selective hydrogenation of α-amino-β-keto esters via dynamic kinetic resolution was achieved for the first time by using the iridium-MeOBIPHEP catalyst in asymmetric synthesis of anti aromatic β-hydroxy-α-amino acid esters with excellent diastereo- and enantioslectivities. Acetic acid as a solvent and sodium acetate as an additive affected dramatically the yield and the enantioselectivity, respectively. The product anti aromatic β-hydroxy-α-amino acid esters are useful for synthesis of pharmaceuticals and natural products. Copyright © 2005 American Chemical Society.

引用

页码：5784 / 5785

页数：2

共 27 条

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