Recent Advances in the Application of Vitamin E TPGS for Drug Delivery

被引：338
作者：
Yang, Conglian [1 ]
Wu, Tingting [1 ]
Qi, Yan [1 ]
Zhang, Zhiping [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Sch Pharm, Wuhan 430030, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430030, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Hubei Engn Res Ctr Novel Drug Delivery Syst, Wuhan 430030, Hubei, Peoples R China
来源：
THERANOSTICS | 2018年 / 8卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Vitamin E; TPGS; drug delivery; multi-drug resistance; anticancer; POLYETHYLENE-GLYCOL SUCCINATE; OVERCOMING MULTIDRUG-RESISTANCE; DOCETAXEL-LOADED NANOPARTICLES; ALPHA-TOCOPHERYL SUCCINATE; SOLID LIPID NANOPARTICLES; P-GLYCOPROTEIN EFFLUX; TARGETED CO-DELIVERY; POORLY SOLUBLE DRUG; EVALUATION IN-VITRO; MIXED MICELLES;
D O I：
10.7150/thno.22711
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
D-alpha-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) has been approved by FDA as a safe adjuvant and widely used in drug delivery systems. The biological and physicochemical properties of TPGS provide multiple advantages for its applications in drug delivery like high biocompatibility, enhancement of drug solubility, improvement of drug permeation and selective antitumor activity. Notably, TPGS can inhibit the activity of ATP dependent P-glycoprotein and act as a potent excipient for overcoming multi-drug resistance (MDR) in tumor. In this review, we aim to discuss the recent advances of TPGS in drug delivery including TPGS based prodrugs, nitric oxide donor and polymers, and unmodified TPGS based formulations. These potential applications are focused on enhancing delivery efficiency as well as the therapeutic effect of agents, especially on overcoming MDR of tumors. It also demonstrates that the clinical translation of TPGS based nanomedicines is still faced with many challenges, which requires more detailed study on TPGS properties and based delivery system in the future.
引用
收藏
页码：464 / 485
页数：22
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