Morphine tolerance after chronic intracerebroventricular injection in male and female mice

被引：17
作者：
Kest, B
Hopkins, E
机构：
[1] CUNY Coll Staten Isl, Dept Psychol, Staten Isl, NY 10314 USA
[2] CUNY Coll Staten Isl, Ctr Dev Neurosci, Staten Isl, NY 10314 USA
[3] CUNY Queens Coll, Neuropsychol Doctoral Subprogram, Flushing, NY 11367 USA
来源：
BRAIN RESEARCH | 2001年 / 892卷 / 01期
关键词：
morphine; tolerance; sex difference; analgesia;
D O I：
10.1016/S0006-8993(00)03301-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We compared morphine analgesia ED50 values of male and female mice prior to (Day 1) and after (Day 4) 3 days of intracerebroventricular morphine injections. Increases in ED50 values from Day 1 to Day 4, indicating tolerance, were of similar magnitude in both sexes. The data suggest that spinal opioid analgesic mechanisms, acting alone or in synergy with supraspinal loci, may contribute to pharmacodynamic explanations of sex differences in systemic morphine tolerance. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：208 / 210
页数：3
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