Histiocytic typhlocolitis in two colony Beagle dogs

被引：8

作者：

Carvallo, Francisco R. ^{[1
]}

Kerlin, Roy ^{[2
]}

Fredette, Claudine ^{[3
]}

Pisharath, Harshan ^{[4
]}

DebRoy, Chitrita ^{[5
]}

Kariyawasam, Subhashinie ^{[6
]}

Pardo, Ingrid D. ^{[2
]}

机构：

[1] Calif Anim Hlth & Food Safety Lab, San Bernardino, CA 92408 USA

[2] Pfizer Inc, Drug Safety Res & Dev, Groton, CT 06340 USA

[3] Pfizer Inc, Pharmatherapeut Res Worldwide Res & Dev, Groton, CT 06340 USA

[4] Nationwide Childrens Hosp, Res Inst, Columbus, OH USA

[5] Penn State Univ, E Coli Reference Ctr, University Pk, PA 16802 USA

[6] Penn State Univ, Dept Vet & Biomed Sci, Anim Diagnost Lab, University Pk, PA 16802 USA

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2015年 / 67卷 / 02期

关键词：

Crohn's disease; Escherichia coli strain LF82; Granulomatous colitis; Ulcerative colitis; ULCERATIVE-COLITIS; BOXER DOGS; GRANULOMATOUS COLITIS; ESCHERICHIA-COLI; WHIPPLES-DISEASE; ADHERENT;

D O I：

10.1016/j.etp.2014.10.004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Two young female Beagle dogs in a laboratory colony with clinical signs of loose stools and fecal blood were confirmed to have histiocytic ulcerative colitis by histologic evaluation. This syndrome is well recognized in other dog breeds such as Boxers and related French Bulldogs, Mastiffs, Alaskan malamutes and Doberman Pinschers. Formalin-fixed paraffin sections of large intestine from one dog demonstrated the presence of Escherichia coli strain LF82 by immunohistochemistry and 16S ribosomal RNA gene sequencing. E coil strain LF82 has been implicated in the pathogenesis of Crohn's disease and similar bacteria have been cultured from cases of histiocytic ulcerative colitis in Boxer dogs. Spontaneous histiocytic ulcerative colitis must be differentiated from test article-related findings in nonclinical toxicity studies in Beagle dogs. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：219 / 221

页数：3

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