Increased risk of varicella zoster virus infection in inflammatory bowel disease in an Asian population: a nationwide population-based cohort study

被引:35
作者
Tsai, S. -Y. [1 ,2 ]
Yang, T. -Y. [3 ,4 ]
Lin, C. -L. [5 ,6 ]
Tsai, Y. -H. [7 ,8 ]
Kuo, C. -F. [9 ]
Kao, C. -H. [10 ,11 ,12 ,13 ]
机构
[1] Mackay Mem Hosp, Dept Lab Med, Taipei, Taiwan
[2] Johns Hopkins Univ, Dept Hlth Policy & Management, Bloomberg Sch Publ Hlth, Baltimore, MD 21218 USA
[3] China Med Univ, China Med Univ Hosp, Mol & Genom Epidemiol Ctr, Taichung 404, Taiwan
[4] Changhua Christian Hosp, Dept Internal Med, Changhua, Taiwan
[5] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan
[6] China Med Univ, Dept Publ Hlth, Taichung 404, Taiwan
[7] Natl Taiwan Univ, Inst Bioengn, Taipei 10764, Taiwan
[8] Far Eastern Mem Hosp, Dept Surg, Taipei, Taiwan
[9] Mackay Mem Hosp, Div Infect Dis, Dept Med, Taipei, Taiwan
[10] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan
[11] China Med Univ Hosp, PET Ctr, Taichung, Taiwan
[12] China Med Univ, Grad Inst Clin Med Sci, Coll Med, Taichung 404, Taiwan
[13] China Med Univ, Sch Med, Coll Med, Taichung 404, Taiwan
关键词
HERPES-ZOSTER; THERAPY; VACCINE; PATHOGENESIS; GENETICS; FEATURES; IMMUNITY; COSTS;
D O I
10.1111/ijcp.12508
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
PurposeWhether patients with inflammatory bowel disease (IBD) exhibit a high risk of developing varicella zoster virus (VZV) infection in Asian populations remains inconclusive. We investigated the causal relationship between two diseases by analysing the Taiwan National Health Insurance Research Database. Patients and methodsBased on a universal insurance claims database, we enrolled 7055 IBD patients and 28,220 age- and sex-matched controls. We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of the herpes zoster virus (HZV) in the IBD and comparison cohorts, using the Cox proportional hazards regression model. ResultsPatients with IBD exhibited significantly higher risk of the HZV compared with the controls (adjusted HRs, 1.42; 95% CI, 1.27-1.60). Further analysis indicated that male patients (adjusted HRs, 1.61; 95% CI, 1.35-1.92), aged 35-44 (adjusted HRs, 1.47; 95% CI, 1.08-2.01) and aged 65years and older (adjusted HRs, 1.47; 95% CI, 1.19-1.80), and patients without comorbidities (adjusted HRs, 1.44; 95% CI, 1.26-1.66), exhibited excessive risks of VZV infection. Moreover, our findings show that the overall risk of developing VZV infection increased risk from 1.03 (95% CI, 0.90-1.18) (2 visits) to 9.76 (95% CI, 7.60-12.5) (>4 visits), which correlates positively with the frequency of medical visits (trend test p<0.0001). ConclusionPatients with IBD, particularly men aged 35-44/65years and over, and patients without comorbidities, are associated with a long-term risk of VZV infection. The excessive risk of VZV infection should be considered for administering vaccines to IBD patients.
引用
收藏
页码:228 / 234
页数:7
相关论文
共 35 条
[1]  
[Anonymous], 2009, six countries, six reform models: the healthcare reform experience of Israel, The Netherlands, New Zealand, Singapore, Switzerland and Taiwan
[2]   Aging, immunity, and the varicella-zoster virus [J].
Arvin, A .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (22) :2266-2267
[3]   Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study [J].
Baron, S ;
Turck, D ;
Leplat, C ;
Merle, V ;
Gower-Rousseau, C ;
Marti, R ;
Yzet, T ;
Lerebours, E ;
Dupas, JL ;
Debeugny, S ;
Salomez, JL ;
Cortot, A ;
Colombel, JF .
GUT, 2005, 54 (03) :357-363
[4]   Gastroenterology 1 - Inflammatory bowel disease: cause and immunobiology [J].
Baumgart, Daniel C. ;
Carding, Simon R. .
LANCET, 2007, 369 (9573) :1627-1640
[5]   The genetics and immunopathogenesis of inflammatory bowel disease [J].
Cho, Judy H. .
NATURE REVIEWS IMMUNOLOGY, 2008, 8 (06) :458-466
[6]   The genetics of inflammatory bowel disease [J].
Cho, Judy H. ;
Weaver, Casey T. .
GASTROENTEROLOGY, 2007, 133 (04) :1327-1339
[8]   Opportunistic Infections Due to Inflammatory Bowel Disease Therapy [J].
Dave, Maneesh ;
Purohit, Treta ;
Razonable, Raymund ;
Loftus, Edward V., Jr. .
INFLAMMATORY BOWEL DISEASES, 2014, 20 (01) :196-212
[9]   Molecular diagnosis of visceral herpes zoster [J].
de Jong, MD ;
Weel, JFL ;
van Oers, MHJ ;
Boom, R ;
Wertheim-van Dillen, PME .
LANCET, 2001, 357 (9274) :2101-2102
[10]   CANCER RISK AND LIFE EXPECTANCY OF CHILDREN WITH ULCERATIVE COLITIS [J].
DEVROEDE, GJ ;
TAYLOR, WF ;
SAUER, WG ;
JACKMAN, RJ ;
STICKLER, GB .
NEW ENGLAND JOURNAL OF MEDICINE, 1971, 285 (01) :17-+