Neocryptolepine (Cryprotackieine), A Unique Bioactive Natural Product: Isolation, Synthesis, and Profile of Its Biological Activity

被引：62

作者：

Bracca, Andrea B. J. ^{[1
,2
]}

Heredia, Daniel A. ^{[1
,2
]}

Larghi, Enrique L. ^{[1
,2
]}

Kaufman, Teodoro S. ^{[1
,2
]}

机构：

[1] Univ Nacl Rosario, Inst Quim Rosario IQUIR CONICET UNR, RA-2000 Rosario, Argentina

[2] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Argentina

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 36期

关键词：

Total synthesis; Natural products; Medicinal chemistry; Alkaloids; Nitrogen heterocycles; Cyclization; DIELS-ALDER REACTION; THERMAL BIRADICAL CYCLIZATIONS; ASSISTED STRUCTURE ELUCIDATION; ONE-POT SYNTHESIS; C-H INSERTION; IN-VITRO; CRYPTOLEPIS-SANGUINOLENTA; INDOLOQUINOLINE ALKALOIDS; INTRAMOLECULAR CYCLIZATION; ANTIMALARIAL ACTIVITY;

D O I：

10.1002/ejoc.201402910

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The widely varying different approaches to the total synthesis of the indoloquinoline alkaloid neocryptolepine are discussed. Aspects relating to the isolation of the natural product from Cryptolepis sanguinolenta, as well as its performance in various biological tests and spectroscopic studies involving the natural product, are also reviewed.

引用

页码：7979 / 8003

页数：25

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