Structural characterization and immunomodulatory activity of a glucan from Radix Codonopsis

被引:24
作者
Li, Jiankuan [1 ]
Wang, Yan [1 ]
Ji, Jiaojiao [1 ]
Cao, Lingya [1 ]
Bai, Yune [1 ]
Gao, Jianping [1 ]
机构
[1] Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan, Peoples R China
关键词
Codonopsis pilosula; Glucan; Polysaccharide; Immunoregulatory activity; POLYSACCHARIDE; PHYTOCHEMISTRY; FRACTION;
D O I
10.1016/j.jff.2021.104537
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
A glucan named as CPC was obtained from the roots of Codonopsis pilosula and its structure was determined by HPGPC, IR, GC-MS, and NMR. HPGPC showed that CPC was a homogeneous polysaccharide and exhibited a molecular weight (Mp) of 1698 Da according to the equation of standard molecular weight (lg Mp = -0.1869 tR + 9.7386). The results from NMR and GC-MS demonstrated that the main linkages in CPC were 1-linked beta-Dglucose, 1,4-linked alpha-D-glucose, and 1,4,6-linked alpha-D-glucose in the molar ratio of 1.0:3.8:1.0, which indicated that the structure of CPC exhibited the backbone of 1,4-linked alpha-D-glucose and the branched chains of 1,6-linked beta-D-glucose. The immunomodulatory activity indicated that CPC showed the significant induction on the productions of NO, ROS, iNOS, TNF-alpha, IL-6, IL-1 beta and IL-10 and the mRNA expressions of iNOS, TNF-alpha, IL-6, IL-1 beta and IL-10 in RAW 246.7 cells. These data suggested that CPC was potential to human health by regulating immunity.
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页数:9
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